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Determination of the properties and loading efficiency of encapsulated BSA-FITC and dexamethasone for drug delivery systems
National Research Tomsk Polytechnic University, Tomsk, Russian Federation.
National Research Tomsk Polytechnic University, Tomsk, Russian Federation.
Mid Sweden University, Faculty of Science, Technology and Media, Department of Quality Management and Mechanical Engineering.ORCID iD: 0000-0003-2964-9500
University of Duisburg-Essen, Essen, Germany.
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2019 (English)In: IOP Conference Series: Materials Science and Engineering, Institute of Physics Publishing (IOPP), 2019, Vol. 597, no 1, article id 012056Conference paper (Refereed)
Abstract [en]

In this work porous microparticles of calcium carbonate were synthesized with bovine serum albumin - fluorescein isothiocyanate conjugate (BSA-FITC) and dexamethasone, and then used for encapsulation in polymer microcapsules by means of layer-by-layer assembly (LbL). The properties of the obtained microcapsules were characterized by scanning electron microscopy, dynamic light scattering, infrared-, ultraviolet- and visible spectroscopy. According to the performed DLS measurements, an average hydrodynamic diameter ranged from 4 to 8 m and zeta-potential for all types of capsules was determined as -18 and -21 mV. BSA-FITC was encapsulated using this approach yielded a loading efficiency of 49 % protein. This value calculated for dexamethasone was of 38%. The microcapsules filled with an encapsulated drug may find applications in the field of biotechnology, biochemistry, and medicine. 

Place, publisher, year, edition, pages
Institute of Physics Publishing (IOPP), 2019. Vol. 597, no 1, article id 012056
Identifiers
URN: urn:nbn:se:miun:diva-37679DOI: 10.1088/1757-899X/597/1/012056Scopus ID: 2-s2.0-85073635032OAI: oai:DiVA.org:miun-37679DiVA, id: diva2:1370306
Conference
16th International Conference of Students and Young Scientists on Prospects of Fundamental Sciences Development, PFSD 2019, Tomsk, Russian Federation, 23 April 2019 through 26 April 2019
Available from: 2019-11-14 Created: 2019-11-14 Last updated: 2019-11-14Bibliographically approved

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Koptioug, Andrei

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