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Identification of potential plasma biomarkers for abdominal aortic aneurysm using tandem mass tag quantitative proteomics
Mid Sweden University, Faculty of Science, Technology and Media, Department of Natural Sciences. Sundsvall County Hospital, Sundsvall.
Sundsvall County Hospital, Sundsvall.
University of Gothenburg, Gothenburg.
University of Gothenburg, Gothenburg.
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2018 (English)In: Proteomes, ISSN 2227-7382, Vol. 6, no 4, article id 43Article in journal (Refereed) Published
Abstract [en]

Plasma biomarkers that identify abdominal aortic aneurysm (AAA) rupture risk would greatly assist in stratifying patients with small aneurysms. Identification of such biomarkers has hitherto been unsuccessful over a range of studies using different methods. The present study used an alternative proteomic approach to find new, potential plasma AAA biomarker candidates. Pre-fractionated plasma samples from twelve patients with AAA and eight matched controls without aneurysm were analyzed by mass spectrometry applying a tandem mass tag (TMT) technique. Eight proteins were differentially regulated in patients compared to controls, including decreased levels of the enzyme bleomycin hydrolase. The down-regulation of this enzyme was confirmed in an extended validation study using an enzyme-linked immunosorbent assay (ELISA). The TMT-based proteomic approach thus identified novel potential plasma biomarkers for AAA. 

Place, publisher, year, edition, pages
2018. Vol. 6, no 4, article id 43
Keywords [en]
Aortic aneurysm, Biomarker, Bleomycin hydrolase, Clinical proteomics, Mass spectrometry, Proteomics
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:miun:diva-35439DOI: 10.3390/proteomes6040043ISI: 000455629200009Scopus ID: 2-s2.0-85059399283OAI: oai:DiVA.org:miun-35439DiVA, id: diva2:1278287
Available from: 2019-01-14 Created: 2019-01-14 Last updated: 2019-03-15Bibliographically approved

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Henriksson, Anders E.Bylund, Dan

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CiteExportLink to record
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