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Identification of potential plasma biomarkers for abdominal aortic aneurysm using tandem mass tag quantitative proteomics
Mittuniversitetet, Fakulteten för naturvetenskap, teknik och medier, Avdelningen för naturvetenskap. Sundsvall County Hospital, Sundsvall.
Sundsvall County Hospital, Sundsvall.
University of Gothenburg, Gothenburg.
University of Gothenburg, Gothenburg.
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2018 (engelsk)Inngår i: Proteomes, ISSN 2227-7382, Vol. 6, nr 4, artikkel-id 43Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Plasma biomarkers that identify abdominal aortic aneurysm (AAA) rupture risk would greatly assist in stratifying patients with small aneurysms. Identification of such biomarkers has hitherto been unsuccessful over a range of studies using different methods. The present study used an alternative proteomic approach to find new, potential plasma AAA biomarker candidates. Pre-fractionated plasma samples from twelve patients with AAA and eight matched controls without aneurysm were analyzed by mass spectrometry applying a tandem mass tag (TMT) technique. Eight proteins were differentially regulated in patients compared to controls, including decreased levels of the enzyme bleomycin hydrolase. The down-regulation of this enzyme was confirmed in an extended validation study using an enzyme-linked immunosorbent assay (ELISA). The TMT-based proteomic approach thus identified novel potential plasma biomarkers for AAA. 

sted, utgiver, år, opplag, sider
2018. Vol. 6, nr 4, artikkel-id 43
Emneord [en]
Aortic aneurysm, Biomarker, Bleomycin hydrolase, Clinical proteomics, Mass spectrometry, Proteomics
HSV kategori
Identifikatorer
URN: urn:nbn:se:miun:diva-35439DOI: 10.3390/proteomes6040043ISI: 000455629200009Scopus ID: 2-s2.0-85059399283OAI: oai:DiVA.org:miun-35439DiVA, id: diva2:1278287
Tilgjengelig fra: 2019-01-14 Laget: 2019-01-14 Sist oppdatert: 2019-03-15bibliografisk kontrollert

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