In many engineering and biomedical problems there is a need to identify parameters of the systems from experimental data. A typical example is the biochemical-kinetics systems describing oncogenic hyperplasia where the dynamical model is nonlinear and the number of the parameters to be identified can reach a few hundreds. Solving these large-scale identification problems by the local- or global-search methods can not be practical because of the complexity and prohibitive computing time. These difficulties can be overcome by application of the non-search techniques which are much less computation- demanding. The present work proposes key components of the corresponding mathematical formulation of the nonsearch paradigm. This new framework for the nonlinear large-scale parameter identification specifies and further develops the ideas of the well-known approach of A. Krasovskii. The issues are illustrated with a concise analytical example. The new results and a few directions for future research are summarized in a dedicated section.