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Microstimulation in The Brain: Does Microdialysis Influence the Activated Volume of Tissue?
University of Luebeck, Institute for Signal Processing. (Biosignal Group)ORCID-id: 0000-0002-5619-409X
University of Luebeck, Institute for Neurology.
University of Luebeck, Institute for Neurology,.
University of Luebeck, Institute for Signal Processing.
2009 (Engelska)Ingår i: Proceedings of the COMSOL Conference Milan 2009, Milan: COMSOL , 2009, , s. 7Konferensbidrag, Publicerat paper (Övrigt vetenskapligt)
Abstract [en]

Deep brain stimulation (DBS) has been established as an effective treatment for Parkinson’s disease and other movement disor- ders. The stimulation is currently administered using tetrode-macroelectrodes that target the subthalamic nucleus (STN). This often leads to side effects which bias the surrounding ar- eas, e.g. the speech centre. Targeting a spe- cific brain region can better be achieved with micro-stimulation electrodes with directed elec- trical field distribution. Experimental studies showed the effectiveness of microelectrode DBS by comparing neurotransmitter outflow before and after the stimulation. The neurotransmit- ter outflow in close proximity to the stimulation is hereby measured by means of microdialysis. To establish ideal distances and stimulation strength, the electric potential around the stim- ulation electrode and microdialysis membrane were modelled using comsol Multiphysics.

Ort, förlag, år, upplaga, sidor
Milan: COMSOL , 2009. , s. 7
Nyckelord [en]
deep brain stimulation, electrode-brain interface, impedance, microdialysis, microelectrodes
Nationell ämneskategori
Industriell bioteknik
Identifikatorer
URN: urn:nbn:se:miun:diva-10625OAI: oai:DiVA.org:miun-10625DiVA, id: diva2:280516
Konferens
COMSOL Conference Milan 2009
Tillgänglig från: 2012-10-12 Skapad: 2009-12-10 Senast uppdaterad: 2012-10-12Bibliografiskt granskad

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Microstimulation in The Brain—Does Microdialysis Influence the Activated Volume of Tissue?(2151 kB)888 nedladdningar
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