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Superior Intrinsic Mitochondria Respiration in Women Than in Men
Swedish Sch Sport & Hlth Sci, Stockholm.
Swedish Sch Sport & Hlth Sci, Stockholm.
Karolinska Inst, Stockholm.
Univ Las Palmas Gran Canaria, Las Palmas Gran Canaria, Spain; Res Inst Biomed & Hlth Sci IUIBS, Las Palmas De Gran Canad, Gran Canaria, Spain.
Vise andre og tillknytning
2018 (engelsk)Inngår i: Frontiers in Physiology, ISSN 1664-042X, E-ISSN 1664-042X, Vol. 9, nr AUG, artikkel-id 1133Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Sexual dimorphism is apparent in humans, however, to date no studies have investigated mitochondria! function focusing on intrinsic mitochondrial respiration (i.e., mitochondrial respiration for a given amount of mitochondrial protein) and mitochondrial oxygen affinity (p50(mito)) in relation to biological sex in human. A skeletal muscle biopsy was donated by nine active women, and ten men matched for maximal oxygen consumption (VO2max) and by nine endurance trained men. Intrinsic mitochondrial respiration, assessed in isolated mitochondria, was higher in women compared to men when activating complex I (Cl-p) and complex I+II(Cl+IIp) (p < 0.05), and was similar to trained men (Cl-p, p = 0.053; Cl+IIp, p = 0.066). Proton leak and p50(mito) to were higher in women compared to men independent of VO2max. In conclusion, significant novel differences in mitochondrial oxidative function, intrinsic mitochondrial respiration and p50(mito) to exist between women and men. These findings may represent an adaptation in the oxygen cascade in women to optimize muscle oxygen uptake to compensate for a lower oxygen delivery during exercise.

sted, utgiver, år, opplag, sider
2018. Vol. 9, nr AUG, artikkel-id 1133
Emneord [en]
sexual dimorphism, mitochondria, endurance performance, mitochondrial function, skeletal muscle, OXPHOS
HSV kategori
Identifikatorer
URN: urn:nbn:se:miun:diva-34516DOI: 10.3389/fphys.2018.01133ISI: 000441955000001PubMedID: 30174617Scopus ID: 2-s2.0-85051673300OAI: oai:DiVA.org:miun-34516DiVA, id: diva2:1251177
Tilgjengelig fra: 2018-09-26 Laget: 2018-09-26 Sist oppdatert: 2018-10-01bibliografisk kontrollert

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