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Isaksson, Dan
Publications (10 of 12) Show all publications
Gylle, M., Isaksson, D. & Ekelund, N. (2009). Research note: Ecotype differentiation in qualitative content of water soluble organic compounds between marine and brackish Fucus vesiculosus L. (Phaeophyceae). Phycological Research, 57(2), 127-130
Open this publication in new window or tab >>Research note: Ecotype differentiation in qualitative content of water soluble organic compounds between marine and brackish Fucus vesiculosus L. (Phaeophyceae)
2009 (English)In: Phycological Research, ISSN 1322-0829, E-ISSN 1440-1835, Vol. 57, no 2, p. 127-130Article in journal (Refereed) Published
Abstract [en]

In the present study we compared the contents of water soluble organic compounds of the marine intertidal ecotype of Fucus vesiculosus (Phaeophyceae) from the Norwegian Sea (34 practical salinity units, psu) with the sublittoral ecotype of F. vesiculosus from the brackish Bothnian Sea (5 psu). Nuclear magnetic resonance spectra revealed that marine F. vesiculosus had additional types of water soluble organic compounds compared with brackish F. vesiculosus. The results suggested that glycine betaine in the marine ecotype could be the reason for this ecotype differentiation. Furthermore, the qualitative differences between the ecotypes were the same after one week's treatment of marine algae in brackish water and of brackish algae in marine water. These suggest that the additional types of water soluble organic compounds in marine F. vesiculosus are not caused by the salinity conditions at the growth sites. Further research concerning other environmental factors that may influence ecotype differentiation of water soluble organic compounds qualitative content and adaptation in F. vesiculosus is recommended.

Keywords
adaptation; Bothnian Sea; C-13 NMR; glycine betaine; mannitol;
National Category
Biological Sciences
Identifiers
urn:nbn:se:miun:diva-7149 (URN)10.1111/j.1440-1835.2009.00529.x (DOI)000266431200006 ()2-s2.0-66149153883 (Scopus ID)
Available from: 2008-11-29 Created: 2008-11-23 Last updated: 2017-12-14Bibliographically approved
Isaksson, D., Sjödin, K. & Högberg, H.-E. (2006). Enantiomerically enriched cryptone by lipase catalysed kinetic resolution. Tetrahedron: asymmetry, 17(2), 275-280
Open this publication in new window or tab >>Enantiomerically enriched cryptone by lipase catalysed kinetic resolution
2006 (English)In: Tetrahedron: asymmetry, ISSN 0957-4166, E-ISSN 1362-511X, Vol. 17, no 2, p. 275-280Article in journal (Refereed) Published
Abstract [en]

Thiophenol was added to racemic cryptone (4-isopropyl-2-cyclohexene-1-one) and the resulting 1,4-addition products, cis- and trans-4-isopropyl-3-(phenylsulfanyl)cyclohexanone) were separated and the latter reduced to rac-1,3-cis-1,4-trans-4-isopropyl-3-(phenylsulfanyl)cyclo¬he¬xanol which was subjected to lipase catalysed resolution by acylation catalysed by CAL-B (Candida antarctica lipase B). The remaining alcohol was separated from the produced acetate, which was hydrolysed to the alcohol. The enantiomeric alcohols so obtained were oxidised. The initial products, probably sulfoxidoketones spontaneously decomposed to furnish enantiomerically enriched (R)- and (S)-cryptone with up to 76% and 98% ee, respectively.

Keywords
cryptone, resolution, lipase, CAL-B
National Category
Chemical Sciences
Identifiers
urn:nbn:se:miun:diva-3720 (URN)10.1016/j.tetasy.2005.12.012 (DOI)000235579500018 ()2-s2.0-32444442897 (Scopus ID)3886 (Local ID)3886 (Archive number)3886 (OAI)
Note

Corrigendum to "Enantiomerically enriched cryptone by lipase catalysed kinetic resolution". [Tetrahedron: Asymmetry 17 (2006) 275] (DOI:10.1016/j.tetasy.2005.12.012)

Tetrahedron Asymmetry Volume 17, Issue 8, 18 April 2006, Page 1318

DOI: 10.1016/j.tetasy.2006.04.028

ScopusID: 2-s2.0-33646837669

Available from: 2008-09-30 Created: 2008-09-30 Last updated: 2017-12-12Bibliographically approved
Isaksson, D., Högberg, H.-E. & Sjödin, K. (2006). Enantioselektiv syntes av seskviterpenen torreyol och andra kadinenderivat: 20:e Organikerdagarna, 12-15 juni 2006, Kalmar, Poster.
Open this publication in new window or tab >>Enantioselektiv syntes av seskviterpenen torreyol och andra kadinenderivat: 20:e Organikerdagarna, 12-15 juni 2006, Kalmar, Poster
2006 (Swedish)Conference paper, Published paper (Other scientific)
Keywords
torreyol
National Category
Chemical Sciences
Identifiers
urn:nbn:se:miun:diva-1342 (URN)4271 (Local ID)4271 (Archive number)4271 (OAI)
Available from: 2008-09-30 Created: 2008-09-30Bibliographically approved
Gylle, A. M., Isaksson, D. & Ekelund, N. (2005). THE CONCENTRATIONS OF MANNITOL IN FUCUS VESICULOSUS AS A RESPONSE TO DIFFERENT SALINITIES. In: PHYCOLOGIA (pp. 42-42).
Open this publication in new window or tab >>THE CONCENTRATIONS OF MANNITOL IN FUCUS VESICULOSUS AS A RESPONSE TO DIFFERENT SALINITIES
2005 (English)In: PHYCOLOGIA, 2005, p. 42-42Conference paper, Published paper (Refereed)
Series
PHYCOLOGIA, ISSN 0031-8884 ; 44-4
Identifiers
urn:nbn:se:miun:diva-11866 (URN)000205501500100 ()
Available from: 2010-07-15 Created: 2010-07-15 Last updated: 2011-04-06Bibliographically approved
Isaksson, D., Högberg, H.-E. & Sjödin, K. (2004). Enantioselektiv syntes av norterpenen Cryptone: 19:e Organikerdagarna, 14-17 juni, Linköping.
Open this publication in new window or tab >>Enantioselektiv syntes av norterpenen Cryptone: 19:e Organikerdagarna, 14-17 juni, Linköping
2004 (Swedish)Conference paper, Published paper (Other scientific)
Keywords
cryptone
National Category
Chemical Sciences
Identifiers
urn:nbn:se:miun:diva-1346 (URN)2457 (Local ID)2457 (Archive number)2457 (OAI)
Available from: 2008-09-30 Created: 2008-09-30Bibliographically approved
Isaksson, D., Lindmark-Henriksson, M., Sjödin, K. & Högberg, H.-E. (2004). Hemiacetals and their esters as side-products in lipase catalysed transesterification of vinyl esters with sterically hindered alcohols. Journal of Molecular Catalysis B: Enzymatic, 31(1-3), 31-37
Open this publication in new window or tab >>Hemiacetals and their esters as side-products in lipase catalysed transesterification of vinyl esters with sterically hindered alcohols
2004 (English)In: Journal of Molecular Catalysis B: Enzymatic, ISSN 1381-1177, E-ISSN 1873-3158, Vol. 31, no 1-3, p. 31-37Article in journal (Refereed) Published
Abstract [en]

Hemiacetals and their esters are formed as side-products in lipase catalysed transesterification of vinyl esters with sterically hindered secondary alcohols. Scope and limitations of the reaction as well as the consequences of it for lipase catalysed kinetic resolutions are discussed.

Keywords
Hemiacetals, Hemiacetal esters, Lipase, seondary alcohols
National Category
Industrial Biotechnology Chemical Sciences
Identifiers
urn:nbn:se:miun:diva-2722 (URN)10.1016/j.molcatb.2004.07.004 (DOI)000224575300005 ()2193 (Local ID)2193 (Archive number)2193 (OAI)
Available from: 2008-09-30 Created: 2008-09-30 Last updated: 2017-12-12Bibliographically approved
Lindmark Henriksson, M., Isaksson, D., Högberg, H.-E., Vanek, T., Valterova, I. & Sjödin, K. (2004). Transformation of terpenes using a Picea abies suspension culture. Journal of Biotechnology, 107(2), 173-184
Open this publication in new window or tab >>Transformation of terpenes using a Picea abies suspension culture
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2004 (English)In: Journal of Biotechnology, ISSN 0168-1656, E-ISSN 1873-4863, Vol. 107, no 2, p. 173-184Article in journal (Refereed) Published
Abstract [en]

When subjected to a Picea abies suspension cell culture, beta-pinene, either one of the pure enantiomers or the racemate, was transformed mainly to trans-pinocarveol along with the minor products myrtenol, alpha-terpineol, pinocarvone, myrtenal and cis-pinocarveol. The absolute configuration of the major products corresponded to that of the starting beta-pinene enantiomer. Some of the primary transformation products, i.e. (1S)-cis- and (1S)-trans-pinocarveol, (1R)-myrtenol and (4S)-alpha-terpineol, were also tested as substrates of the P. abies suspension culture. They reacted more slowly than beta-pinene but, except for (4S)-alpha-terpineol, they were all transformed. Thus, (1R)-myrtenol was converted into both (1R)-myrtenal and (1R)-myrtanol, whereas (1S)-trans-pinocarveol was converted into (1S)-pinocarvone. (4R)-Limonene was slowly transformed by the suspension culture into limonene-(1,2)-epoxide as the major product, with carveol, perillyl alcohol and 1,8-cineole as minor products. Autoxidation of terpenes in cell-free nutrient medium was investigated in detail. alpha-Pinene and beta-pinene were both autoxidized to a certain extent, while limonene remained unaffected. The rate of the autoxidation was more than one order of magnitude slower than that of the biotransformation. Moreover, different products were formed by autoxidation than by biotransformation.

Keywords
terpenes
National Category
Chemical Sciences
Identifiers
urn:nbn:se:miun:diva-1545 (URN)10.1016/j.jbiotec.2003.10.009 (DOI)000188203500008 ()2-s2.0-0346724932 (Scopus ID)448 (Local ID)448 (Archive number)448 (OAI)
Available from: 2008-09-30 Created: 2008-09-30 Last updated: 2017-12-13Bibliographically approved
Isaksson, D., Lindmark Henriksson, M., Sjödin, K. & Högberg, H.-E. (2003). Hemiacetal ester formation in lipase catalysed transesterifications of vinyl esters with hindered secondary alcohols: Meeting abstract. In: ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. Paper presented at 225th National Meeting of the American-Chemical-Society, Mar 23-27, 2003, New Orleans, Louisiana.
Open this publication in new window or tab >>Hemiacetal ester formation in lipase catalysed transesterifications of vinyl esters with hindered secondary alcohols: Meeting abstract
2003 (English)In: ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2003Conference paper, Published paper (Refereed)
Series
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, ISSN 0065-7727 ; 225 Part 2
Keywords
lipase
National Category
Chemical Sciences
Identifiers
urn:nbn:se:miun:diva-6624 (URN)000187918001848 ()446 (Local ID)446 (Archive number)446 (OAI)
Conference
225th National Meeting of the American-Chemical-Society, Mar 23-27, 2003, New Orleans, Louisiana
Available from: 2009-02-24 Created: 2009-02-24 Last updated: 2011-07-26Bibliographically approved
Lindmark-Henriksson, M., Isaksson, D., Sjödin, K., Högberg, H.-E., Vanek, T. & Valterova, I. (2003). Transformation of alpha-pinene using Picea abies suspension culture. Journal of Natural Products, 66(3), 337-343
Open this publication in new window or tab >>Transformation of alpha-pinene using Picea abies suspension culture
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2003 (English)In: Journal of Natural Products, ISSN 0163-3864, Vol. 66, no 3, p. 337-343Article in journal (Refereed) Published
Abstract [en]

alpha-Pinene, both as the pure enantiomers and as the racemate, was transformed mainly to trans-verbenol by treatment with a Picea abies suspension cell culture. These reactions were followed by a slow transformation of the verbenol to verbenone, which was not transformed further. trans-Pinocarveol, myrtenol, cis-verbenol, and alpha-terpineol were byproducts of intermediate abundance. When subjected to the action of the suspension culture, cis-verbenol was not only transformed to verbenone but also isomerized to trans-verbenol. The transformation of alpha-pinene was fast, and the products were detected within one minute. The absolute configuration of the major products corresponded to that of the starting alpha-pinene enantiomer

Keywords
Suspension Culture
National Category
Chemical Sciences
Identifiers
urn:nbn:se:miun:diva-1538 (URN)10.1021/np020426m (DOI)000181923100004 ()2-s2.0-0037349145 (Scopus ID)440 (Local ID)440 (Archive number)440 (OAI)
Available from: 2008-09-30 Created: 2008-09-30 Last updated: 2016-10-21Bibliographically approved
Högberg, H.-E., Lindmark, M., Isaksson, D., Sjödin, K., Franssen, M., Jongejan, H., . . . de Groot, A. (2000). Formation of hemiacetal esters in lipase-catalysed reactions of vinyl esters with hindered secondary alcohols. Tetrahedron Letters, 41(17), 3193-3196
Open this publication in new window or tab >>Formation of hemiacetal esters in lipase-catalysed reactions of vinyl esters with hindered secondary alcohols
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2000 (English)In: Tetrahedron Letters, ISSN 0040-4039, E-ISSN 1359-8562, Vol. 41, no 17, p. 3193-3196Article in journal (Refereed) Published
Keywords
enzyme catalysis, hemiacetal esters
National Category
Chemical Sciences
Identifiers
urn:nbn:se:miun:diva-2280 (URN)10.1016/S0040-4039(00)00328-2 (DOI)000086892600043 ()0038709784 (Scopus ID)1856 (Local ID)1856 (Archive number)1856 (OAI)
Available from: 2008-09-30 Created: 2008-09-30 Last updated: 2017-12-12Bibliographically approved
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