miun.sePublications
Change search
Link to record
Permanent link

Direct link
BETA
Vigetun-Haughey, Helena
Alternative names
Publications (10 of 10) Show all publications
Vigetun-Haughey, H., Appelberg, J., Forsberg, T., Kaldensjö, M. & Schagatay, E. (2015). Voluntary apnea evokes diving responses in obstructive sleep apnea patients. European Journal of Applied Physiology, 115(5), 1029-1036
Open this publication in new window or tab >>Voluntary apnea evokes diving responses in obstructive sleep apnea patients
Show others...
2015 (English)In: European Journal of Applied Physiology, ISSN 1439-6319, E-ISSN 1439-6327, Vol. 115, no 5, p. 1029-1036Article in journal (Refereed) Published
Abstract [en]

Two potentially protective responses to apnea were studied in obstructive sleep apnea (OSA) patients; the diving response and the increase in Hb concentration [Hb] via spleen contraction. Eight OSA patients and ten healthy controls performed apneas in air (A) and apneas with facial immersion in 15 A degrees C water (FIA) after inspiration and without prior hyperventilation. In each condition, subjects performed three apneas of maximal voluntary duration spaced by 2 min of rest. Cardiorespiratory parameters were measured non-invasively, and venous blood samples for [Hb] analysis were drawn before and after apneas. Mean (SD) apnea durations were similar between groups (NS). In controls, the heart rate (HR) reduction was 10 +/- A 10 % at apnea and 19 +/- A 10 % in FIA (P < 0.05). In OSA patients, however, the fall in HR was the same in both conditions, 13 +/- A 10 and 14 +/- A 8 % for A and FIA, respectively (NS). In controls, the [Hb] increase was the same in A and FIA (2.2 +/- A 2.9 and 2.1 +/- A 2.2 %), while in OSA the [Hb] increase was greater during FIA compared to A (3.3 +/- A 2.2 and 1.4 +/- A 0.9 %; P < 0.05). Apnea induces a diving response and [Hb] increase in both groups. OSA patients did not show the typical training effect of the diving response seen in apnea divers despite their frequent nocturnal apneas. However, they also deviated from normal controls in response pattern; face immersion enhanced the cardiovascular diving response in controls but not in OSA, while the hematological response was enhanced by face immersion only in OSA patients.

Keywords
Training, Spleen contraction, Hypoxia, Hypercapnia, Hb, Bradycardia, OSA, Hemoglobin
National Category
Sport and Fitness Sciences
Identifiers
urn:nbn:se:miun:diva-25686 (URN)10.1007/s00421-014-3083-7 (DOI)000352721500016 ()25549785 (PubMedID)2-s2.0-84928313816 (Scopus ID)
Available from: 2015-08-27 Created: 2015-08-18 Last updated: 2017-12-04Bibliographically approved
Vigetun, H., Appelberg, J., Forsberg, T., Kaldensjö, M. & Schagatay, E. (2011). Diving response and Hb elevation during voluntary apnea in patients with obstructive sleep apnea.. In: SFSS congress proceedings. Paper presented at SFSS annual congress 25-27 May 2011, Örebro, Sweden.
Open this publication in new window or tab >>Diving response and Hb elevation during voluntary apnea in patients with obstructive sleep apnea.
Show others...
2011 (English)In: SFSS congress proceedings, 2011Conference paper, Published paper (Refereed)
Keywords
sleep medicine, defence, hypoxia, diving physiology, OSA
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:miun:diva-15401 (URN)
Conference
SFSS annual congress 25-27 May 2011, Örebro, Sweden
Projects
Kardiovaskulär regleringIntegrativ fysiologi
Available from: 2011-12-19 Created: 2011-12-19 Last updated: 2011-12-20Bibliographically approved
de Bruijn, R., Richardson, M., Haughey, H., Björklund, G., Pettersson, S. & Schagatay, E. (2005). High hemoglobin levels in divers may be a result of apnea induced EPO-production. In: FASEB JOURNAL. Paper presented at Experimental Biology 2005 Meeting/35th International Congress of Physiological Sciences, Mar 31-Apr 06, 2005, San Diego CA (pp. A211-A212).
Open this publication in new window or tab >>High hemoglobin levels in divers may be a result of apnea induced EPO-production
Show others...
2005 (English)In: FASEB JOURNAL, 2005, p. A211-A212Conference paper, Published paper (Refereed)
Abstract [en]

Oxygen storage capacity is important for apneic duration and affects performance in endurance sports. We studied if hemoglobin concentration (Hb) was different in divers compared to endurance athletes and untrained subjects and if any differences could be connected to training-induced erythropoietin (EPO) -production. We first compared Hb in 3 groups of subjects: 13 elite apneic divers (35±4 years), 13 elite cross-country skiers (20±1 years) and 23 untrained subjects (29±1 years) with similar weight and height. After 20 min of horizontal rest blood samples were drawn and analysed for Hb using standard methods. In a second experiment, we compared EPO levels before and after a series of 15 maximal apneas in air in 9 previously untrained volunteers (302 years). Apneas were spaced by 2 minutes, the last minute with hyperventilation to produce durations long enough to induce hypoxia. Values were also compared to the EPO levels of a control day without apneas. The apneic divers had higher Hb than untrained subjects (P<0.05) and skiers (P<0.01). After apnea training in untrained subjects EPO levels increased in all subjects, with a mean peak value after 3 h, where the increase was 135 % of the pre apnea value (P<0.05). No increase was observed during the same time period of the control day. We concluded that higher Hb levels in apneic divers may be a result of enhanced EPO-production due to the apnea training.

Series
FASEB JOURNAL, ISSN 0892-6638 ; 19-4
Keywords
EPO
National Category
Microbiology Sport and Fitness Sciences
Identifiers
urn:nbn:se:miun:diva-2789 (URN)000227610701334 ()2313 (Local ID)2313 (Archive number)2313 (OAI)
Conference
Experimental Biology 2005 Meeting/35th International Congress of Physiological Sciences, Mar 31-Apr 06, 2005, San Diego CA
Available from: 2008-09-30 Created: 2009-07-27 Last updated: 2011-04-12Bibliographically approved
Richardson, M., de Bruijn, R., Holmberg, H.-C., Björklund, G., Haughey, H. & Schagatay, E. (2005). Increase of hemoglobin concentration after maximal apneas in divers, skiers and untrained humans. Canadian Journal of Applied Physiology, 30(3), 276-281
Open this publication in new window or tab >>Increase of hemoglobin concentration after maximal apneas in divers, skiers and untrained humans
Show others...
2005 (English)In: Canadian Journal of Applied Physiology, ISSN 1066-7814, Vol. 30, no 3, p. 276-281Article in journal (Refereed) Published
Abstract [en]

Apnea is physiologically stressful and can within a short time frame pose a threat to survival. To sustain prolonged apnea, oxygen use should be minimized and its storage maximized. Two mechanisms known to have this effect are the cardiovascular diving response, directing the available oxygen selectively to the heart and brain, and spleen contraction increasing the circulating erythrocyte volume and thereby gas storage capacity. Spleen contraction is also observed after maximal exercise, and is thought to enhance aerobic performance. While the cardiovascular diving response is known to be more pronounced after apnea training, spleen contraction has not been studied in conjunction with apnea training or other types of training. The aim of the present investigation is to study the hematological responses to apnea performed during rest by elite apneic divers, by elite cross-country skiers and by untrained subjects. After 20 min of rest, subjects performed 3 maximal apneas spaced by 2 min normal breathing intervals. Blood samples were drawn before, directly after, and 10 min after the apnea series and hemoglobin concentration was measured. All groups responded to maximal apneas with an increase in hemoglobin concentration, which had disappeared after 10 min of recovery. The increase in hemoglobin concentration was more pronounced in the apneic divers (4g/L) than in skiers (3g/L) and untrained subjects (2g/L; P < 0.05). All groups prolonged their apneic times through the series, but the increase was most evident for the divers versus both the skiers (P < 0.05) and untrained subjects (P < 0.01). The results suggest that these responses could be more pronounced as a result of apnea training.

Keywords
apnea, hemoglobin, endurance training, cross country skiing, spleen contraction
National Category
Microbiology Biological Sciences Sport and Fitness Sciences
Identifiers
urn:nbn:se:miun:diva-1688 (URN)000229602800002 ()1516 (Local ID)1516 (Archive number)1516 (OAI)
Note
VR-Medicine, ExternalAvailable from: 2008-09-30 Created: 2009-07-27 Last updated: 2011-04-06Bibliographically approved
Schagatay, E., Haughey, H. & Reimers, J. (2005). Speed of spleen volume changes evoked by serial apneas. European Journal of Applied Physiology, 93(4), 447-452
Open this publication in new window or tab >>Speed of spleen volume changes evoked by serial apneas
2005 (English)In: European Journal of Applied Physiology, ISSN 1439-6319, E-ISSN 1439-6327, Vol. 93, no 4, p. 447-452Article in journal (Refereed) Published
Abstract [en]

Diving mammals may enhance dive duration by injecting extra erythrocytes into the circulation by spleen contraction. This mechanism may also be important for apneic duration in humans. We studied the speed and magnitude of spleen volume changes evoked by serial apneas, and the associated changes in hematocrit (Hct) and hemoglobin (Hb) concentration, diving response and apneic duration. Three maximal apneas separated by 2 min rest elicited spleen contraction in all ten subjects, by a mean of 49 (27) ml (18%; P<0.001). During the same period, Hct and Hb rose by 2.2 and 2.4% respectively (P<0.01 and P<0.001), and apneic duration rose by 20 s (22% P<0.05). The mean heart rate reduction of the diving response was 15%, which remained the same throughout the apnea series. While the diving response was completely reversed between the apneas, spleen size was not recovered until 8–9 min after the final apnea corresponding with recovery of Hct and Hb. Thus, although the spleen contraction may be associated with the cardiovascular diving response, it is likely to be triggered by different mechanisms, and it may remain activated between dives spaced by short pauses. The two adjustments may provide a fast, quickly reversed, and a slow, but long-lasting, way of shifting to a diving mode in humans

Keywords
Speed of spleen volume changes evoked by serial apneas.
National Category
Microbiology Sport and Fitness Sciences
Identifiers
urn:nbn:se:miun:diva-2195 (URN)10.1007/s00421-004-1224-0 (DOI)000225911900010 ()1592 (Local ID)1592 (Archive number)1592 (OAI)
Note
VR-Medicine, ExternalAvailable from: 2008-09-30 Created: 2009-06-08 Last updated: 2017-12-12Bibliographically approved
de Bruijn, R., Richardson, M., Haughey, H., Holmberg, H.-C., Björklund, G. & Schagatay, E. (2004). Hemoglobin levels in elite divers, elite skiers and untrained humans.
Open this publication in new window or tab >>Hemoglobin levels in elite divers, elite skiers and untrained humans
Show others...
2004 (English)Conference paper, Published paper (Other academic)
Keywords
fysiologi, blod, prestation
National Category
Sport and Fitness Sciences
Identifiers
urn:nbn:se:miun:diva-4585 (URN)5743 (Local ID)5743 (Archive number)5743 (OAI)
Available from: 2008-09-30 Created: 2009-07-27 Last updated: 2011-04-12Bibliographically approved
Schagatay, E., Richardson, M., de Bruijn, R., Haughey, H. & Holmberg, H. C. (2004). Naturlig bloddopning vid fysiologisk stress. Svensk idrottsforskning, 13(1), 18-21
Open this publication in new window or tab >>Naturlig bloddopning vid fysiologisk stress
Show others...
2004 (Swedish)In: Svensk idrottsforskning, ISSN 1103-4629, Vol. 13, no 1, p. 18-21Article in journal (Other academic) Published
Keywords
apné, bloddopning, hematokrit
National Category
Sport and Fitness Sciences
Identifiers
urn:nbn:se:miun:diva-4583 (URN)5738 (Local ID)5738 (Archive number)5738 (OAI)
Available from: 2008-09-30 Created: 2008-09-30 Last updated: 2011-04-06Bibliographically approved
Richardson, M., Schagatay, E., de Bruijn, R. & Haughey, H. (2003). Hematological response pattern associated with maximal-duration apnea series in untrained subjects: Annual Meeting of the European Underwater and Baromedical Society, Copenhagen, Denmark..
Open this publication in new window or tab >>Hematological response pattern associated with maximal-duration apnea series in untrained subjects: Annual Meeting of the European Underwater and Baromedical Society, Copenhagen, Denmark.
2003 (English)Conference paper, Published paper (Other academic)
Abstract [en]

Background: In addition to the human cardiovascular ‘diving response’, i.e., bradycardia and peripheral vasoconstriction during apnea, recent studies have shown that spleen contraction also occurs during repeated apneas. This latter response may serve to expel erythrocytes into the circulation to promote gas transportation. However, prospective changes in blood parameters after repeated apneas have yet to be systematically described. As is the case with diving response parameters, some individuals may have stronger haematological changes from performing apneic series than others. These variations need to be considered in future studies of the function of the spleen and blood components during apnea. The present study was aimed to describe the haematological response pattern associated with repeated maximal apneas in healthy non-divers. Methods: After 20 min of rest, 46 healthy untrained subjects of both sexes performed three maximal apneas, spaced by two minutes rest and normal breathing. Blood samples were taken before, within 1 minute after, and 10 minutes after the apneic series and analyzed for changes in haemoglobin (Hb) concentration and hematocrit (Hct). Results: Pre-apnea Hb concentration (mean±SE) was normally distributed (147.1±1.6 g/L). An increase of 2.1±0.3% in the Hb value was seen immediately post-series, followed by a decrease from this value of 1.8±0.3% at 10 minutes post-series. Pre-apnea hematocrit (41.2±0.6 percent) showed a similar increase immediately post-series of 3.2±0.8% followed by a decrease of 1.6±0.4% from this value at 10 minutes post-series. Classifying subjects as strong responders (above 75th percentile) and weak responders (below 25th percentile) resulted in mean increases in Hb and Hct above pre-apneic values of 4.7±0.4% and 7.1±2.1%, respectively for strong responders, and -0.5±0.4 and 0.5±0.6, respectively for weak responders. Conclusion: Significant increases in Hb and Hct values occur immediately after a maximal apneic series, followed by a return towards baseline values after 10 minutes. These increases may be due to the spleen contraction as demonstrated in previous research. Furthermore, some subjects appear to respond more strongly than others, and pre-screening for these types of responders may be judicious in future testing. The mechanism(s) underlying the strength of these haematological responses warrants further investigation.

Keywords
hematocrit, hemoglobin, spleen contraction, apnea
National Category
Microbiology
Identifiers
urn:nbn:se:miun:diva-1034 (URN)1518 (Local ID)1518 (Archive number)1518 (OAI)
Available from: 2008-09-30 Created: 2008-09-30 Last updated: 2011-04-06Bibliographically approved
Schagatay, E., Haughey, H. & Reimers, J. (2003). Spleen volume changes evoked by serial apneas: Underwater and Baromedical Society (EUBS) meeting Copenhagen.
Open this publication in new window or tab >>Spleen volume changes evoked by serial apneas: Underwater and Baromedical Society (EUBS) meeting Copenhagen
2003 (English)Conference paper, Published paper (Other academic)
Keywords
Spleen volume changes evoked by serial apneas
National Category
Microbiology Sport and Fitness Sciences Physiology
Identifiers
urn:nbn:se:miun:diva-4858 (URN)1531 (Local ID)1531 (Archive number)1531 (OAI)
Available from: 2008-09-30 Created: 2008-09-30 Last updated: 2018-01-12Bibliographically approved
Richardson, M., de Bruijn, R., Haughey, H., Andersson, J. & Schagatay, E. (2003). The incidence of hematocrit increase during apnea in non divers: European Underwater and Baromedical Society (EUBS) meeting Copenhagen, Denmark.
Open this publication in new window or tab >>The incidence of hematocrit increase during apnea in non divers: European Underwater and Baromedical Society (EUBS) meeting Copenhagen, Denmark
Show others...
2003 (English)Conference paper, Published paper (Other academic)
Keywords
apnea
National Category
Microbiology Sport and Fitness Sciences Physiology
Identifiers
urn:nbn:se:miun:diva-606 (URN)1535 (Local ID)1535 (Archive number)1535 (OAI)
Available from: 2008-09-30 Created: 2008-09-30 Last updated: 2018-01-13Bibliographically approved
Organisations

Search in DiVA

Show all publications