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Axelsson, Inge
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Publications (10 of 98) Show all publications
Irevall, T., Axelsson, I. & Naumburg, E. (2017). B12 deficiency is common in infants and is accompanied by serious neurological symptons. Acta Paediatrica, 106(1), 101-104
Open this publication in new window or tab >>B12 deficiency is common in infants and is accompanied by serious neurological symptons
2017 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 106, no 1, p. 101-104Article in journal (Refereed) Published
Abstract [en]

Aim

Adverse neurological symptoms have been linked to vitamin B12 deficiency in infants. This explorative study described the clinical presentation associated with vitamin B12 deficiency in this age group.

Methods

The study comprised infants who were born between 2004 and 2012 and were tested for vitamin B12 levels after they were admitted to a hospital with neurological symptoms at less than one year of age. Vitamin B12 deficiency was defined as low cobalamin in serum and/or increased homocysteine and/or increased methylmalonate. It was diagnosed according to the applicable International Classification of Diseases, 10th revision, and recorded as vitamin B12 deficiency in the medical records. All information was retrieved from medical records and compared to symptomatic infants with normal levels.

Results

Of the 121 infants tested, 35 had vitamin B12 deficiency and 86 had normal levels. Vitamin B12 deficiency was diagnosed at an average age of 1.7 months and was more common among boys. Seizures and apparent life-threatening events were the most common symptoms among infants with B12 deficiency compared to infants with normal levels.

Conclusion

Vitamin B12 deficiency was more common in infants than we expected and presented with severe symptoms, such as seizures and apparent life-threatening events.

National Category
Pediatrics
Identifiers
urn:nbn:se:miun:diva-29657 (URN)10.1111/apa.13625 (DOI)
Available from: 2016-12-18 Created: 2016-12-18 Last updated: 2017-12-18Bibliographically approved
Axelsson, I. & Lind, J. (2017). Kriminalisera kärnvapen. In: Edith Andresen, Gustav Lidén, Sara Nyhlén (Ed.), Hållbarhetens många ansikten: samtal, forskning och fantasier (pp. 102-107). Sundsvall: Mid Sweden University
Open this publication in new window or tab >>Kriminalisera kärnvapen
2017 (Swedish)In: Hållbarhetens många ansikten: samtal, forskning och fantasier / [ed] Edith Andresen, Gustav Lidén, Sara Nyhlén, Sundsvall: Mid Sweden University , 2017, p. 102-107Chapter in book (Other academic)
Place, publisher, year, edition, pages
Sundsvall: Mid Sweden University, 2017
Series
Genusstudier vid Mittuniversitetet, ISSN 1654-5753 ; 13
National Category
Social Sciences
Identifiers
urn:nbn:se:miun:diva-32318 (URN)978-91-88527-37-0 (ISBN)
Available from: 2017-12-07 Created: 2017-12-07 Last updated: 2017-12-07
Naumburg, E., Söderström, L., Huber, D. & Axelsson, I. (2017). Risk factors for pulmonary arterial hypertension in children and young adults. Pediatric Pulmonology, 52(5), 636-641
Open this publication in new window or tab >>Risk factors for pulmonary arterial hypertension in children and young adults
2017 (English)In: Pediatric Pulmonology, ISSN 8755-6863, E-ISSN 1099-0496, Vol. 52, no 5, p. 636-641Article in journal (Refereed) Published
Abstract [en]

Objectives

Pulmonary hypertension (PH) has been linked to preterm birth explained by congenital heart defects and pulmonary diseases.

Working hypothesis

Other factors may influence the risk of PH among adolescences and children born premature.

Study design

This national registry-based study assess risk of PH following premature birth adjusted for known risk factors.

Patient-subject selection and methodology

All cases born 1993–2010, identified by diagnostic codes applicable to PH and retrieved from the Swedish Registry of Congenital Heart Disease (N = 67). Six controls were randomly selected and matched to each case by year of birth and hospital by the Swedish Medical Birth Register (N = 402). Maternal and infant data related to preterm birth, pulmonary diseases, and congenital defects were retrieved. The association between preterm birth and pulmonary hypertension was calculated by conditional logistic regression taking into account potential confounding factors.

Results

One third of the cases and seven percent of the controls were born preterm in our study. Preterm birth was associated with PH, OR = 8.46 (95%CI 2.97–24.10) (P < 0.0001) even after adjusting for confounding factors. Other factors, such as acute pulmonary diseases, congenital heart defects, congenital diaphragm herniation, and chromosomal disorders were also associated with PH in the multivariate analysis.

Conclusions

Children and young adults born preterm are known to have an increased risk of PH, previously explained by congenital heart defects and pulmonary diseases. By adjusting for such factors, our study indicates that new factors may play a role in the risk of developing PH among children born preterm. 

National Category
Pediatrics
Identifiers
urn:nbn:se:miun:diva-29655 (URN)10.1002/ppul.23633 (DOI)
Available from: 2016-12-18 Created: 2016-12-18 Last updated: 2017-12-14Bibliographically approved
Axelsson, I., Bergström, S.-E., Hermansson, A., Tessin, I., Hellberg, C., Mowafi, F. & Granath, A. A. (2016). Behandling av luftvägsinfektioner hos barn med läkemedel och andra preparat. Stockholm: SBU
Open this publication in new window or tab >>Behandling av luftvägsinfektioner hos barn med läkemedel och andra preparat
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2016 (Swedish)Report (Refereed)
Place, publisher, year, edition, pages
Stockholm: SBU, 2016. p. 80
Series
SBU kartlägger, ISSN 1400-1403 ; 251/2016
National Category
Pediatrics
Identifiers
urn:nbn:se:miun:diva-29663 (URN)978-91-85413-94-2 (ISBN)
Available from: 2016-12-19 Created: 2016-12-19 Last updated: 2016-12-19Bibliographically approved
Axelsson, I. (2016). Hårdnad konkurrens ger dopad forskning. Stockholm: SvD Kultur
Open this publication in new window or tab >>Hårdnad konkurrens ger dopad forskning
2016 (Swedish)Other (Other (popular science, discussion, etc.))
Place, publisher, year, pages
Stockholm: SvD Kultur, 2016
National Category
Medical Ethics
Identifiers
urn:nbn:se:miun:diva-29664 (URN)
Available from: 2016-12-19 Created: 2016-12-19 Last updated: 2016-12-19Bibliographically approved
Edler, G., Axelsson, I., Barker, G. M., Lie, S. & Naumburg, E. (2016). Serious complications in male infant circumcisions in Scandinavia indicate that this always be performed as a hospital-based procedure. Acta Paediatrica, 105(7), 842-850
Open this publication in new window or tab >>Serious complications in male infant circumcisions in Scandinavia indicate that this always be performed as a hospital-based procedure
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2016 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 105, no 7, p. 842-850Article in journal (Refereed) Published
Abstract [en]

Aim:More than 7000 male circumcisions are performed in Scandinavia every year. Circumcision is regulated in different ways in Sweden and Denmark and Norway. This study reviewed and described factors associated with complications of circumcision in infant boys in Scandinavia over the last two decades and discussed how these complications could be avoided. Methods: Data on significant complications following circumcision on boys under the age of one in Scandinavia over the last 20 years were collected. Information was retrieved from testimonies of circumcisers, witnesses, medical records and verdicts. A systematic review was performed of fatal cases in the literature. Results: We found that 32 cases had been reported to the health authorities in the three countries, and we identified a total of 74 complications in these cases. These included four boys with severe bleeding and circulatory shock, which ended in the death of one boy.Other less serious complications may have occurred in other boys, but not been reported. Conclusion: Complications following male circumcision in Scandinavia were relatively rare,but serious complications did occur. Based on the analyses of the severe cases, we argue that circumcision should only be performed at hospitals with 24-hour emergency departments.

National Category
Pediatrics
Identifiers
urn:nbn:se:miun:diva-29658 (URN)10.1111/apa.13402 (DOI)
Available from: 2016-12-18 Created: 2016-12-18 Last updated: 2017-11-29Bibliographically approved
Axelsson, I. (2016). Sverige måste agera för en kärnvapenfri värld 2030. Göteborg: GP
Open this publication in new window or tab >>Sverige måste agera för en kärnvapenfri värld 2030
2016 (Swedish)Other (Other (popular science, discussion, etc.))
Place, publisher, year, pages
Göteborg: GP, 2016
Series
GP Debatt
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
urn:nbn:se:miun:diva-29665 (URN)
Available from: 2016-12-19 Created: 2016-12-19 Last updated: 2016-12-19Bibliographically approved
Edler, G., Axelsson, I., Barker, G. M., Lie, S. & Naumburg, E. (2016). Säkerheten vid omskärelse av pojkar måste bli bättre. Läkartidningen, 113, Article ID D4CC.
Open this publication in new window or tab >>Säkerheten vid omskärelse av pojkar måste bli bättre
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2016 (Swedish)In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 113, article id D4CCArticle in journal (Other academic) Published
National Category
Pediatrics
Identifiers
urn:nbn:se:miun:diva-29659 (URN)
Available from: 2016-12-18 Created: 2016-12-18 Last updated: 2017-08-09Bibliographically approved
Axelsson, I. (2016). Så blir vi bättre på att delta i Cochranesamarbetet. Läkartidningen, 113-113, Article ID ECW7.
Open this publication in new window or tab >>Så blir vi bättre på att delta i Cochranesamarbetet
2016 (Swedish)In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, p. 113-113, article id ECW7Article in journal (Other academic) Published
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
urn:nbn:se:miun:diva-29656 (URN)
Available from: 2016-12-18 Created: 2016-12-18 Last updated: 2017-08-09Bibliographically approved
Naumburg, E., Axelsson, I., Huber, D. & Soderstrom, L. (2015). Some neonatal risk factors for adult pulmonary arterial hypertension remain unknown. Acta Paediatrica, 104(11), 1104-1108
Open this publication in new window or tab >>Some neonatal risk factors for adult pulmonary arterial hypertension remain unknown
2015 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 104, no 11, p. 1104-1108Article in journal (Refereed) Published
Abstract [en]

Aim: Pulmonary hypertension has been linked to premature birth, chronic lung disease, bronchopulmonary dysplasia and congenital heart disease. This national population-based registry study assessed the risk of adult pulmonary hypertension following premature birth, adjusted for known risk factors.

Methods: We focused on adults in the Swedish Pulmonary Arterial Hypertension Registry, who were born prematurely, and controls randomly selected from the Swedish medical birth register and matched to each case by birth year and delivery hospital. Information on perinatal factors was also retrieved from the medical birth register. Conditional multiple logistic regression was used to evaluate the association between premature birth and adult pulmonary hypertension, taking into account the potential confounding factors.

Results: The study population comprised 427 adults born between 1973 and 1996, with 61 cases and 366 controls. Adult pulmonary hypertension was associated with premature birth, with an odds ratio of 3.08 and 95% confidence interval of 1.21-7.87. The association did not alter after adjusting for potential confounders.

Conclusion: By adjusting for factors linked to adult pulmonary hypertension, namely congenital heart defects, pulmonary diseases and premature birth, we were able to show that other unknown factors may influence the risk for pulmonary hypertension among adults who were born premature.

Keywords
Brochopulmonary dysplasia, Chronic lung disease, Premature birth, Pulmonary Hypertension, Risk factors
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:miun:diva-26566 (URN)10.1111/apa.13205 (DOI)000363866200023 ()26346500 (PubMedID)2-s2.0-84984837937 (Scopus ID)
Available from: 2015-12-17 Created: 2015-12-17 Last updated: 2018-02-28Bibliographically approved
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