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Popov, V. V. ., Muller-Kamskii, G., Katz-Demyanetz, A., Kovalevsky, A., Usov, S., Trofimcow, D., . . . Koptioug, A. (2019). Additive manufacturing to veterinary practice: recovery of bony defects after the osteosarcoma resection in canines. BIOMEDICAL ENGINEERING LETTERS, 9(1), 97-108
Open this publication in new window or tab >>Additive manufacturing to veterinary practice: recovery of bony defects after the osteosarcoma resection in canines
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2019 (English)In: BIOMEDICAL ENGINEERING LETTERS, ISSN 2093-9868, Vol. 9, no 1, p. 97-108Article, review/survey (Refereed) Published
Abstract [en]

The paper outlines the achievements and challenges in the additive manufacturing (AM) application to veterinary practice. The state-of-the-art in AM application to the veterinary surgery is presented, with the focus of AM for patient-specific implants manufacturing. It also provides critical discussion on some of the potential issues design and technology should overcome for wider and more effective implementation of additively manufactured parts in veterinary practices. Most of the discussions in present paper are related to the metallic implants, manufactured in this case using so-called powder bed additive manufacturing (PB-AM) in titanium alloy Ti-6AL-4V, and to the corresponding process of their design, manufacturing and implementation in veterinary surgery. Procedures of the implant design and individualization for veterinary surgery are illustrated basing on the four performed surgery cases with dog patients. Results of the replacement surgery in dogs indicate that individualized additively manufactured metallic implants significantly increase chances for successful recovery process, and AM techniques present a viable alternative to amputation in a large number of veterinary cases. The same time overcoming challenges of implant individualization in veterinary practice significantly contributes to the knowledge directly relevant to the modern medical practice. An experience from veterinary cases where organ-preserving surgery with 3D-printed patient-specific implants is performed provides a unique opportunity for future development of better human implants.

Keywords
Additive manufacturing, Ti-6Al-4V, Implants, Veterinary applications of 3D printing, Clinical cases, Osteosarcoma, Dogs
National Category
Biomedical Laboratory Science/Technology
Identifiers
urn:nbn:se:miun:diva-36157 (URN)10.1007/s13534-018-00092-7 (DOI)000462195200009 ()30956883 (PubMedID)2-s2.0-85063445924 (Scopus ID)
Available from: 2019-05-20 Created: 2019-05-20 Last updated: 2019-05-23Bibliographically approved
Chudinova, E. A., Surmeneva, M. A., Timin, A. S., Karpov, T. E., Wittmar, A., Ulbricht, M., . . . Surmenev, R. A. (2019). Adhesion, proliferation, and osteogenic differentiation of human mesenchymal stem cells on additively manufactured Ti6Al4V alloy scaffolds modified with calcium phosphate nanoparticles. Colloids and Surfaces B: Biointerfaces, 176, 130-139
Open this publication in new window or tab >>Adhesion, proliferation, and osteogenic differentiation of human mesenchymal stem cells on additively manufactured Ti6Al4V alloy scaffolds modified with calcium phosphate nanoparticles
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2019 (English)In: Colloids and Surfaces B: Biointerfaces, ISSN 0927-7765, E-ISSN 1873-4367, Vol. 176, p. 130-139Article in journal (Refereed) Published
Abstract [en]

In the present study, biocomposites based on 3D porous additively manufactured Ti6Al4V (Ti64) scaffolds modified with biocompatible calcium phosphate nanoparticles (CaPNPs) were investigated. Ti64 scaffolds were manufactured via electron beam melting technology using an Arcam machine. Electrophoretic deposition was used to modify the scaffolds with CaPNPs, which were synthesized by precipitation in the presence of polyethyleneimine (PEI). Dynamic light scattering revealed that the CaP/PEI nanoparticles had an average size of 46 ± 18 nm and a zeta potential of +22 ± 9 mV. Scanning electron microscopy (SEM) revealed that the obtained spherical CaPNPs had an average diameter of approximately 90 nm. The titanium-based scaffolds coated with CaPNPs exhibited improved hydrophilic surface properties, with a water contact angle below 5°. Cultivation of human mesenchymal stem cells (hMSCs) on the CaPNPs-coated Ti64 scaffolds indicated that the improved hydrophilicity was beneficial for the attachment and growth of cells in vitro. The Ti6Al4V/CaPNPs scaffold supported an increase in the alkaline phosphatase (ALP) activity of cells. In addition to the favourable cell proliferation and differentiation, Ti6Al4V/CaPNPs scaffolds displayed increased mineralization compared to non-coated Ti6Al4V scaffolds. Thus, the developed composite 3D scaffolds of Ti6Al4V functionalized with CaPNPs are promising materials for different applications related to bone repair. 

Keywords
Additive manufacturing, Calcium phosphate, Cell adhesion, Electron beam melting, Electrophoretic deposition, Nanoparticles, Proliferation in vivo, Scaffold, Surface properties
Identifiers
urn:nbn:se:miun:diva-35415 (URN)10.1016/j.colsurfb.2018.12.047 (DOI)000465051800016 ()30597410 (PubMedID)2-s2.0-85059137646 (Scopus ID)
Available from: 2019-01-10 Created: 2019-01-10 Last updated: 2019-05-22Bibliographically approved
Surmeneva, M., Lapanje, A., Chudinova, E., Ivanova, A., Koptioug, A., Loza, K., . . . Surmenev, R. (2019). Decreased bacterial colonization of additively manufactured Ti6Al4V metallic scaffolds with immobilized silver and calcium phosphate nanoparticles. Applied Surface Science, 480, 822-829
Open this publication in new window or tab >>Decreased bacterial colonization of additively manufactured Ti6Al4V metallic scaffolds with immobilized silver and calcium phosphate nanoparticles
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2019 (English)In: Applied Surface Science, ISSN 0169-4332, E-ISSN 1873-5584, Vol. 480, p. 822-829Article in journal (Refereed) Published
Abstract [en]

The design of an ideal bone graft substitute has been a long-standing effort, and a number of strategies have been developed to improve bone regeneration. Electron beam melting (EBM) is an additive manufacturing method allowing for the production of porous implants with highly defined external dimensions and internal architectures. The increasing surface area of the implant may also increase the abilities of pathogenic microorganisms to adhere to the surfaces and form a biofilm, which may result in serious complications. The aim of this study was to explore the modifications of Ti6Al4V alloy scaffolds to reduce the abilities of bacteria to attach to the EBM-manufactured implant surface. The layers composed of silver (Ag), calcium phosphate (CaP) nanoparticles (NPs) and combinations of both were formed on the EBM-fabricated metallic scaffolds by electrophoretic deposition in order to provide them with antimicrobial properties. The assay of bacterial colonization on the surface was performed with the exposure of scaffold surfaces to Staphylococcus aureus cells for up to 17 h. Principal component analysis (PCA) was used to assess the relationships between different surface features of the studied samples and bacterial adhesion. The results indicate that by modifying the implant surface with appropriate nanostructures that change the hydrophobicity and the surface roughness at the nano scale, physical cues are provided that disrupt bacterial adhesion. Our results clearly show that AgNPs at a concentration of approximately 0.02 mg/сm 2 that were deposited together with CaPNPs covered by positively charge polyethylenimine (PEI) on the surface of EBM-sintered Ti6Al4V scaffolds hindered bacterial growth, as the total number of attached cells (NAC) of S. aureus remained at the same level during the 17 h of exposure, which indicates bacteriostatic activity. 

Keywords
Additive manufacturing, Antimicrobial assay, Bacteriostatic activity, Electron beam melting, Electrophoretic deposition, Nanoparticles
Identifiers
urn:nbn:se:miun:diva-35863 (URN)10.1016/j.apsusc.2019.03.003 (DOI)000463008200092 ()2-s2.0-85062680211 (Scopus ID)
Available from: 2019-03-25 Created: 2019-03-25 Last updated: 2019-05-22Bibliographically approved
Petrone, N., Candiotto, G., Marzella, E., Uriati, F., Carraro, G., Bäckström, M. & Koptyug, A. (2019). Feasibility of using a novel instrumented human head surrogate to measure helmet, head and brain kinematics and intracranial pressure during multidirectional impact tests. Journal of Science and Medicine in Sport, 22(S1), S78-S84
Open this publication in new window or tab >>Feasibility of using a novel instrumented human head surrogate to measure helmet, head and brain kinematics and intracranial pressure during multidirectional impact tests
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2019 (English)In: Journal of Science and Medicine in Sport, ISSN 1440-2440, E-ISSN 1878-1861, Vol. 22, no S1, p. S78-S84Article in journal (Refereed) Published
Abstract [en]

Objectives: Aim of the work is to present the feasibility of using an Instrumented Human Head Surrogate (IHHS-1) during multidirectional impacts while wearing a modern ski helmet. The IHHS-1 is intended to provide reliable and repeatable data for the experimental validation of FE models and for the experimental evaluation of modern helmets designed to enhance the degree of protection against multidirectional impacts. Design: The new IHHS-1 includes 9 triaxial MEMS accelerometers embedded in a silicone rubber brain, independently molded and presenting lobes separation and cerebellum, placed into an ABS skull filled with surrogate cerebrospinal fluid. A triaxial MEMS gyroscope is placed at the brain center of mass. Intracranial pressure can be detected by eight pressure sensors applied to the skull internal surface along a transversal plane located at the brain center of mass and two at the apex. Additional MEMS sensors positioned over the skull and the helmet allow comparison between outer and inner structure kinematics and surrogate CSF pressure behavior. Methods: The IHHS-1 was mounted through a Hybrid III neck on a force platform and impacted with a striker connected to a pendulum tower, with the impact energies reaching 24J. Impact locations were aligned with the brain center of mass and located in the back (sagittal axis), right (90° from sagittal axis), back/right (45°), and front right (135°) locations. Following dynamic data were collected: values of the linear accelerations and angular velocities of the brain, skull and helmet; intracranial pressures inside the skull. Results: Despite the relatively low intensity of impacts (HIC at skull max value 46), the skull rotational actions reached BrIC values of 0.33 and angular accelerations of 5216 rad/s2, whereas brain angular acceleration resulted between 1,44 and 2,1 times lower with similar values of BrIC. Conclusions: The IHHS-1 is a physical head surrogate that can produce repeatable data for the interpretation of inner structures behavior during multidirectional impacts with or without helmets of different characteristics. 

Keywords
Accelerometers, Angular velocity, Helmet evaluation, Human head, Intracranial pressure, Surrogate
National Category
Materials Engineering
Identifiers
urn:nbn:se:miun:diva-36704 (URN)10.1016/j.jsams.2019.05.015 (DOI)
Available from: 2019-07-10 Created: 2019-07-10 Last updated: 2019-09-30Bibliographically approved
Norris, K., Mishukova, O. I., Zykwinska, A., Colliec-Jouault, S., Sinquin, C., Koptioug, A., . . . Douglas, T. E. L. (2019). Marine Polysaccharide-Collagen Coatings on Ti6Al4V Alloy Formed by Self-Assembly. Micromachines, 10(1), Article ID 68.
Open this publication in new window or tab >>Marine Polysaccharide-Collagen Coatings on Ti6Al4V Alloy Formed by Self-Assembly
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2019 (English)In: Micromachines, ISSN 2072-666X, E-ISSN 2072-666X, Vol. 10, no 1, article id 68Article in journal (Refereed) Published
Abstract [en]

Polysaccharides of marine origin are gaining interest as biomaterial components. Bacteria derived from deep-sea hydrothermal vents can produce sulfated exopolysaccharides (EPS), which can influence cell behavior. The use of such polysaccharides as components of organic, collagen fibril-based coatings on biomaterial surfaces remains unexplored. In this study, collagen fibril coatings enriched with HE800 and GY785 EPS derivatives were deposited on titanium alloy (Ti6Al4V) scaffolds produced by rapid prototyping and subjected to physicochemical and cell biological characterization. Coatings were formed by a self-assembly process whereby polysaccharides were added to acidic collagen molecule solution, followed by neutralization to induced self-assembly of collagen fibrils. Fibril formation resulted in collagen hydrogel formation. Hydrogels formed directly on Ti6Al4V surfaces, and fibrils adsorbed onto the surface. Scanning electron microscopy (SEM) analysis of collagen fibril coatings revealed association of polysaccharides with fibrils. Cell biological characterization revealed good cell adhesion and growth on bare Ti6Al4V surfaces, as well as coatings of collagen fibrils only and collagen fibrils enhanced with HE800 and GY785 EPS derivatives. Hence, the use of both EPS derivatives as coating components is feasible. Further work should focus on cell differentiation.

National Category
Mechanical Engineering
Identifiers
urn:nbn:se:miun:diva-35809 (URN)10.3390/mi10010068 (DOI)000459735300067 ()30669427 (PubMedID)
Available from: 2019-03-19 Created: 2019-03-19 Last updated: 2019-03-19Bibliographically approved
Katz-Demyanetz, A., Popov, V. V. ., Kovalevsky, A., Safranchik, D. & Koptioug, A. (2019). Powder-bed additive manufacturing for aerospace application: Techniques, metallic and metal/ceramic composite materials and trends. MANUFACTURING REVIEW, 6, Article ID 5.
Open this publication in new window or tab >>Powder-bed additive manufacturing for aerospace application: Techniques, metallic and metal/ceramic composite materials and trends
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2019 (English)In: MANUFACTURING REVIEW, ISSN 2265-4224, Vol. 6, article id 5Article, review/survey (Refereed) Published
Abstract [en]

The current paper is devoted to classification of powder-bed additive manufacturing (PB-AM) techniques and description of specific features, advantages and limitation of different PB-AM techniques in aerospace applications. The common principle of "powder-bed" means that the used feedstock material is a powder, which forms "bed-like" platform of homogeneous layer that is fused according to cross-section of the manufactured object. After that, a new powder layer is distributed with the same thickness and the "printing" process continues. This approach is used in selective laser sintering/melting process, electron beam melting, and binder jetting printing. Additionally, relevant issues related to powder raw materials (metals, ceramics, multi-material composites, etc.) and their impact on the properties of as-manufactured components are discussed. Special attention is paid to discussion on additive manufacturing (AM) of aerospace critical parts made of Titanium alloys, Nickel-based superalloys, metal matrix composites (MMCs), ceramic matrix composites (CMCs) and high entropy alloys. Additional discussion is related to the quality control of the PB-AM materials, and to the prospects of new approaches in material development for PB-AM aiming at aerospace applications.

Keywords
Additive manufacturing, Aerospace materials, High entropy alloys, Powder-bed, Superalloys, Titanium alloys
Identifiers
urn:nbn:se:miun:diva-36168 (URN)10.1051/mfreview/2019003 (DOI)000462342700001 ()2-s2.0-85063930317 (Scopus ID)
Available from: 2019-05-20 Created: 2019-05-20 Last updated: 2019-05-24Bibliographically approved
Radulov, I. A., Popov, V. J., Koptioug, A., Maccari, F., Kovalevsky, A., Essel, S., . . . Bamberger, M. (2019). Production of net-shape Mn-Al permanent magnets by electron beam melting. Additive Manufacturing, 30, Article ID 100787.
Open this publication in new window or tab >>Production of net-shape Mn-Al permanent magnets by electron beam melting
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2019 (English)In: Additive Manufacturing, ISSN 2214-8604, Vol. 30, article id 100787Article in journal (Refereed) Published
Abstract [en]

The main goal of this work is the adoption of additive manufacturing for the production of inexpensive rare-earth free MnAl-based permanent magnets. The use of more advanced binder-free additive manufacturing technique such as Electron Beam Melting (EBM) allows obtaining fully-dense magnetic materials with advanced topology and complex shapes. We focus on the feasibility of controlling the phase formation in additively manufactured Mn-Al alloys by employing post-manufacturing heat treatment. The as-manufactured EBM samples contain 8% of the desired ferromagnetic τ-MnAl phase. After the optimized annealing treatment, the content of the τ-phase was increased to 90%. This sample has a coercivity value of 0.15 T, which is also the maximum achieved in conventionally produced binary MnAl magnets. Moreover, the EBM samples are fully dense and have the same density as the samples produced by conventional melting density. 

Keywords
Additive manufacturing, Electron beam melting, Mn-Al alloys, Permanent magnets, Printed magnets
Identifiers
urn:nbn:se:miun:diva-37310 (URN)10.1016/j.addma.2019.100787 (DOI)2-s2.0-85072229290 (Scopus ID)
Available from: 2019-09-24 Created: 2019-09-24 Last updated: 2019-09-24Bibliographically approved
Popov, V. V., Katz-Demyanetz, A., Koptioug, A. & Bamberger, M. (2019). Selective electron beam melting of Al0.5CrMoNbTa0.5 high entropy alloys using elemental powder blend. Heliyon, 5(2), Article ID e01188.
Open this publication in new window or tab >>Selective electron beam melting of Al0.5CrMoNbTa0.5 high entropy alloys using elemental powder blend
2019 (English)In: Heliyon, ISSN 2405-8440, Vol. 5, no 2, article id e01188Article in journal (Refereed) Published
Abstract [en]

High Entropy Alloys (HEAs) is a novel promising class of multi-component materials which may demonstrate superior mechanical properties useful for high-temperature applications. Despite the high potential of HEAs, their production is complicated, using pre-alloyed powders in powder metallurgy route. This significantly complicates development and implementation of refractory BCC solid solution based HEAs. The present paper reports on experiments aiming at production of Al0.5CrMoNbTa0.5 multi-principle alloy using powder bed beam based additive manufacturing. Samples were manufactured using Selective Electron Beam Melting (SEBM) additive manufacturing technique from a blend of elemental powders aiming at achieving microstructure with high configurational entropy. Though it was not possible to achieve completely homogeneous microstructure, the as-printed material was composed of the zones with two multi-component solid solutions, which differed only by Al content confirming in situ alloying. The process parameters optimization was not carried out and the as-print material contained a notable amount of residual porosity. It was possible to reach lower porosity level using heat treatment at 1300 °C for 24 hours, however undesirable alloy composition changes took place. The main conclusion is that the production of the Al0.5CrMoNbTa0.5 multi-principle alloy from elemental powder blends using SEBM technique is achievable, but the process parameter optimization rather than post-process heat treatment should be performed to reduce the porosity of samples. 

Keywords
Materials science, Metallurgical engineering
National Category
Electrical Engineering, Electronic Engineering, Information Engineering
Identifiers
urn:nbn:se:miun:diva-35826 (URN)10.1016/j.heliyon.2019.e01188 (DOI)000460082200017 ()30839937 (PubMedID)2-s2.0-85061049225 (Scopus ID)
Available from: 2019-03-19 Created: 2019-03-19 Last updated: 2019-03-25Bibliographically approved
Chudinova, E., Surmeneva, M., Koptioug, A., Loza, K., Prymak, O., Epple, M. & Surmenev, R. (2019). Surface modification of Ti6Al4V alloy scaffolds manufactured by electron beam melting. In: Godymchuk A.,Rieznichenko L.,Semenov M. (Ed.), : . Paper presented at 15th International Conference of Students and Young Scientists on Prospects of Fundamental Sciences Development, PFSD 2018, 24 April 2018 through 27 April 2018. Institute of Physics Publishing (IOPP) (1)
Open this publication in new window or tab >>Surface modification of Ti6Al4V alloy scaffolds manufactured by electron beam melting
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2019 (English)In: / [ed] Godymchuk A.,Rieznichenko L.,Semenov M., Institute of Physics Publishing (IOPP), 2019, no 1Conference paper, Published paper (Refereed)
Abstract [en]

In this paper, the results of the surface functionalization of the Ti6Al4V alloy scaffolds with different structures for use as a material for medical implants are presented. Radio frequency magnetron sputtering was used to modify the surface of the porous structures by deposition of the biocompatible hydroxyapatite (HA) coating with the thickness of 86050 nm. The surface morphology, elemental and phase composition of the HA-coated scaffolds were studied. According to energy-dispersive X-ray spectroscopy, the stoichiometric ratio of Ca/P for flat, orthorhombic and cubic scaffolds is 1.65, 1.60, 1.53, respectively, which is close to that of stoichiometric ratio for HA (Ca/P = 1.67). It was revealed that this method of deposition makes it possible to obtain the homogeneous crystalline coating both on the dense sample and in the case of scaffolds of complex geometry with different lattice cell structure. 

Place, publisher, year, edition, pages
Institute of Physics Publishing (IOPP), 2019
Series
Journal of Physics: Conference Series, ISSN 1742-6588, E-ISSN 1742-6596
National Category
Mechanical Engineering
Identifiers
urn:nbn:se:miun:diva-35814 (URN)10.1088/1742-6596/1145/1/012030 (DOI)2-s2.0-85060053396 (Scopus ID)
Conference
15th International Conference of Students and Young Scientists on Prospects of Fundamental Sciences Development, PFSD 2018, 24 April 2018 through 27 April 2018
Available from: 2019-03-19 Created: 2019-03-19 Last updated: 2019-03-19Bibliographically approved
Khrapov, D., Surmeneva, M., Koptioug, A., Evsevleev, S., Lé Onard, F., Bruno, G. & Surmenev, R. (2019). X-ray computed tomography of multiple-layered scaffolds with controlled gradient cell lattice structures fabricated via additive manufacturing. In: : . Paper presented at 15th International Conference of Students and Young Scientists on Prospects of Fundamental Sciences Development, PFSD 2018, 24 April 2018 through 27 April 2018. Institute of Physics Publishing (IOPP), 1145(1), Article ID 012044.
Open this publication in new window or tab >>X-ray computed tomography of multiple-layered scaffolds with controlled gradient cell lattice structures fabricated via additive manufacturing
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2019 (English)Conference paper, Published paper (Refereed)
Abstract [en]

In this paper we report on the characterization by X-ray computed tomography of calcium phosphate (CaP) and polycaprolactone (PCL) coatings on Ti-6Al-4V alloy scaffolds used as a material for medical implants. The cylindrical scaffold has greater porosity of the inner part than the external part, thus, mimicking trabecular and cortical bone, respectively. The prismatic scaffolds have uniform porosity. Surface of the scaffolds was modified with calcium phosphate (CaP) and polycaprolactone (PCL) by dip-coating to improve biocompatibility and mechanical properties. Computed tomography performed with X-ray and synchrotron radiation revealed the defects of structure and morphology of CaP and PCL coatings showing small platelet-like and spider-web-like structures, respectively. 

Place, publisher, year, edition, pages
Institute of Physics Publishing (IOPP), 2019
Series
Journal of Physics: Conference Series, ISSN 1742-6588, E-ISSN 1742-6596
National Category
Mechanical Engineering
Identifiers
urn:nbn:se:miun:diva-35815 (URN)10.1088/1742-6596/1145/1/012044 (DOI)2-s2.0-85060005564 (Scopus ID)
Conference
15th International Conference of Students and Young Scientists on Prospects of Fundamental Sciences Development, PFSD 2018, 24 April 2018 through 27 April 2018
Available from: 2019-03-19 Created: 2019-03-19 Last updated: 2019-03-19Bibliographically approved
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ORCID iD: ORCID iD iconorcid.org/0000-0003-2964-9500

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