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Sjöström, W., Koptyug, A., Rännar, L.-E. & Botero, C. (2024). Near-infrared radiation: A promising heating method for powder bed fusion. Materials and Manufacturing Processes, 39(3), 320-328
Open this publication in new window or tab >>Near-infrared radiation: A promising heating method for powder bed fusion
2024 (English)In: Materials and Manufacturing Processes, ISSN 1042-6914, E-ISSN 1532-2475, Vol. 39, no 3, p. 320-328Article in journal (Refereed) Published
Abstract [en]

Metal additive manufacturing technologies, such as electron beam powder bed fusion (PBF-EB), rely on layer heating to overcome the so-called “smoke” phenomenon. When scaled up for industrial manufacturing, PBF-EB becomes less productive due to the lengthy preheating process. Currently, only the electron beam (EB) is used for preheating in PBF-EB, resulting in increased manufacturing times, energy consumption, and in some cases limiting the applicability of the technology. In this study, a new preheating approach is suggested that incorporates a near-infrared radiation (NIR) emitter inside an PBF-EB system. The NIR unit eliminates the need for EB heating, reducing build time and powder charging. Successful builds using 316 L and Ti6Al4V precursor powders validate the feasibility of the proposed approach. The produced samples exhibit similar properties to those obtained by the standard PBF-EB process. The introduction of NIR technology also reduced build cost and increased the service intervals of the electron gun. 

Place, publisher, year, edition, pages
Informa UK Limited, 2024
Keywords
316L, additive, beam, Electron, infrared, manufacturing, Ti6Al4V
National Category
Materials Engineering
Identifiers
urn:nbn:se:miun:diva-48165 (URN)10.1080/10426914.2023.2195910 (DOI)000961192700001 ()2-s2.0-85152071465 (Scopus ID)
Available from: 2023-04-19 Created: 2023-04-19 Last updated: 2024-02-27Bibliographically approved
Zullo, G., Baldoin, E., Koptyug, A., Bäckström, M. & Petrone, N. (2023). Advances in the development of a instrumented head surrogate for brain injury investigation. In: Convegno Nazionale di Bioingegneria: . Paper presented at Convegno Nazionale di Bioingegneria 2023:8th National Congress of Bioengineering, GNB 2023, Padova21 June 2023 through 23 June, 2023. Patron Editore S.r.l.
Open this publication in new window or tab >>Advances in the development of a instrumented head surrogate for brain injury investigation
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2023 (English)In: Convegno Nazionale di Bioingegneria, Patron Editore S.r.l. , 2023Conference paper, Published paper (Refereed)
Abstract [en]

Acquiring knowledge on head traumas is useful since they represent a dangerous outcome of traumatic events. Injury criteria aim to link clinical evidence of injury with experimentally measurable physical quantities, however, recent studies based on numerical methods have pointed out that also other factors could be key contributors to brain injury probability and severity. Providing an experimental measure of more advanced injury criteria is challenging, and only few research groups have started to address the problem. Starting from an existing and validated biofidelic dummy head, advances in the mechanical components and sensors embedded inside the model have been carried out, aiming to improve both bio-fidelity and to address the measure of more advanced criteria. After realizing the prototype, preliminary drop tests were performed impacting the helmeted head over an anvil. Data collected showed increase of injury criteria values with the impact force. Results proved the possibility of using the surrogate for investigating simple and advanced injury criteria, and future works will aim to set test parameters to levels compatible with helmet standards.

Place, publisher, year, edition, pages
Patron Editore S.r.l., 2023
Keywords
head injury, impact test, protective headgear, surrogate head
National Category
Mechanical Engineering
Identifiers
urn:nbn:se:miun:diva-49849 (URN)2-s2.0-85175792307 (Scopus ID)9788855580113 (ISBN)
Conference
Convegno Nazionale di Bioingegneria 2023:8th National Congress of Bioengineering, GNB 2023, Padova21 June 2023 through 23 June, 2023
Available from: 2023-11-14 Created: 2023-11-14 Last updated: 2023-11-14Bibliographically approved
Kozadaeva, M., Surmeneva, M., Khrapov, D., Rybakov, V., Surmenev, R., Koptyug, A., . . . Grubova, I. (2023). Assessment of Microstructural, Mechanical and Electrochemical Properties of Ti–42Nb Alloy Manufactured by Electron Beam Melting. Materials, 16(13), Article ID 4821.
Open this publication in new window or tab >>Assessment of Microstructural, Mechanical and Electrochemical Properties of Ti–42Nb Alloy Manufactured by Electron Beam Melting
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2023 (English)In: Materials, ISSN 1996-1944, E-ISSN 1996-1944, Vol. 16, no 13, article id 4821Article in journal (Refereed) Published
Abstract [en]

The β-type Ti–42Nb alloy has been successfully manufactured from pre-alloyed powder using the E-PBF method for the first time. This study presents thorough microstructural investigations employing diverse methodologies such as EDS, XRD, TEM, and EBSD, while mechanical properties are assessed using UPT, nanoindentation, and compression tests. Microstructural analysis reveals that Ti–42Nb alloy primarily consisted of the β phase with the presence of a small amount of nano-sized α″-martensite formed upon fast cooling. The bimodal-grained microstructure of Ti–42Nb alloy comprising epitaxially grown fine equiaxed and elongated equiaxed β-grains with an average grain size of 40 ± 28 µm exhibited a weak texture. The study shows that the obtained microstructure leads to improved mechanical properties. Young’s modulus of 78.69 GPa is significantly lower than that of cp-Ti and Ti–6Al–4V alloys. The yield strength (379 MPa) and hardness (3.2 ± 0.5 GPa) also meet the criteria and closely approximate the values typical of cortical bone. UPT offers a reliable opportunity to study the nature of the ductility of the Ti–42Nb alloy by calculating its elastic constants. XPS surface analysis and electrochemical experiments demonstrate that the better corrosion resistance of the alloy in SBF is maintained by the dominant presence of TiO2 and Nb2O5. The results provide valuable insights into the development of novel low-modulus Ti–Nb alloys, which are interesting materials for additive-manufactured implants with the desired properties required for their biomedical applications. 

Place, publisher, year, edition, pages
MDPI, 2023
Keywords
additive manufacturing, corrosion resistance, implant material, mechanical properties, Ti–2Nb alloy, β type Ni-free Ti alloy
National Category
Metallurgy and Metallic Materials
Identifiers
urn:nbn:se:miun:diva-49038 (URN)10.3390/ma16134821 (DOI)001032322400001 ()2-s2.0-85164825181 (Scopus ID)
Available from: 2023-08-15 Created: 2023-08-15 Last updated: 2023-08-25Bibliographically approved
Koptioug, A. & Bäckström, M. (2023). Body Part Surrogates for Medicine, Comfort and Safety Applications. In: Sharma, Ashutosh (Ed.), Advances in 3D Printing: . Rijeka: IntechOpen
Open this publication in new window or tab >>Body Part Surrogates for Medicine, Comfort and Safety Applications
2023 (English)In: Advances in 3D Printing / [ed] Sharma, Ashutosh, Rijeka: IntechOpen , 2023Chapter in book (Refereed)
Abstract [en]

<i>Advances in 3D Printing</i> presents an overview of various types of advances in 3D printing. It discusses current research trends, problems, and applications of 3D printing processes and materials. The book also discusses advances in bioprinting, tissue generation, radiotherapy, and safety issues in health care. It showcases applications of 3D printing in digital design, body part surrogates, rheological models, airway stents, 3D-printed cermets, and more. It also discusses advances in biomimetic nanocomposite materials, intellectual property concerns, and safety issues in 3D printing technology.

Place, publisher, year, edition, pages
Rijeka: IntechOpen, 2023
National Category
Materials Engineering
Identifiers
urn:nbn:se:miun:diva-50826 (URN)10.5772/intechopen.110119 (DOI)978-1-80355-844-8 (ISBN)
Available from: 2024-03-05 Created: 2024-03-05 Last updated: 2024-03-05Bibliographically approved
Grubova, I. Y., Surmenev, R. A., Neyts, E. C., Koptyug, A. V., Volkova, A. P. & Surmeneva, M. A. (2023). Combined First-Principles and Experimental Study on the Microstructure and Mechanical Characteristics of the Multicomponent Additive-Manufactured Ti-35Nb-7Zr-5Ta Alloy. ACS Omega, 8(30), 27519-27533
Open this publication in new window or tab >>Combined First-Principles and Experimental Study on the Microstructure and Mechanical Characteristics of the Multicomponent Additive-Manufactured Ti-35Nb-7Zr-5Ta Alloy
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2023 (English)In: ACS Omega, E-ISSN 2470-1343, Vol. 8, no 30, p. 27519-27533Article in journal (Refereed) Published
Abstract [en]

New & beta;-stabilizedTi-based alloys are highly promising forbone implants, thanks in part to their low elasticity. The natureof this elasticity, however, is as yet unknown. We here present combinedfirst-principles DFT calculations and experiments on the microstructure,structural stability, mechanical characteristics, and electronic structureto elucidate this origin. Our results suggest that the studied & beta;Ti-35Nb-7Zr-5Ta wt % (TNZT) alloy manufacturedby the electron-beam powder bed fusion (E-PBF) method has homogeneousmechanical properties (H = 2.01 & PLUSMN; 0.22 GPa and E = 69.48 & PLUSMN; 0.03 GPa) along the building direction,which is dictated by the crystallographic texture and microstructuremorphologies. The analysis of the structural and electronic properties,as the main factors dominating the chemical bonding mechanism, indicatesthat TNZT has a mixture of strong metallic and weak covalent bonding.Our calculations demonstrate that the softening in the Cauchy pressure(C & PRIME; = 98.00 GPa) and elastic constant C &#x305; ( 44 ) = 23.84 GPa is the originof the low elasticity of TNZT. Moreover, the nature of this softeningphenomenon can be related to the weakness of the second and thirdneighbor bonds in comparison with the first neighbor bonds in theTNZT. Thus, the obtained results indicate that a carefully designedTNZT alloy can be an excellent candidate for the manufacturing oforthopedic internal fixation devices. In addition, the current findingscan be used as guidance not only for predicting the mechanical propertiesbut also the nature of elastic characteristics of the newly developedalloys with yet unknown properties.

Place, publisher, year, edition, pages
American Chemical Society (ACS), 2023
National Category
Metallurgy and Metallic Materials
Identifiers
urn:nbn:se:miun:diva-49053 (URN)10.1021/acsomega.3c03157 (DOI)001031269000001 ()37546645 (PubMedID)2-s2.0-85166770456 (Scopus ID)
Available from: 2023-08-16 Created: 2023-08-16 Last updated: 2023-08-16Bibliographically approved
Botero, C., Koptyug, A., Sjöström, W., Jiménez-Piqué, E., Şelte, A. & Rännar, L.-E. (2023). Functionally Graded Steels Obtained via Electron Beam Powder Bed Fusion. Key Engineering Materials, 964, 79-84
Open this publication in new window or tab >>Functionally Graded Steels Obtained via Electron Beam Powder Bed Fusion
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2023 (English)In: Key Engineering Materials, ISSN 1013-9826, E-ISSN 1662-9795, Vol. 964, p. 79-84Article in journal (Refereed) Published
Abstract [en]

Electron-Beam Powder Bed Fusion (EB-PBF) is one of the most important metal additive manufacturing (AM) technologies. In EB-PBF, a focused electron beam is used to melt metal powders in a layer by layer approach. In this investigation two pre-alloyed steel-based powders, stainless steel 316L and V4E, a tool steel developed by Uddeholm, were used to manufacture functionally graded materials. In the proposed approach two powders are loaded into the feeding container, V4E powder on top of 316L one, preventing their mixing. Such type of feeding yields components with two distinct materials separated by a zone with gradual transition from 316L to V4E. Microstructure and local mechanical properties were evaluated in the manufactured samples. Optical Microscopy, Scanning Electron Microscopy and EDX on the polished cross-sections show a gradual microstructural and compositional transition from characteristic 316L at the bottom of the specimens to the tool steel towards the top. Nanoindentation experiments confirmed a consequent gradient in hardness and elastic modulus, which gradually increase towards the top surface of the samples. The achieved results provide great possibilities to tailor the composition, microstructure, mechanical properties, and wear resistance by combining different powders in the powder bed AM technology. Potential applications include the tooling industry, where hard and wear-resistant materials are demanded on the surface with tougher and more ductile materials in the core of the tool.

Place, publisher, year, edition, pages
Trans Tech Publications, Ltd., 2023
Keywords
Electron Beam Melting, Functional Graded Materials (FGMs), Nanoindentation, Steel
National Category
Metallurgy and Metallic Materials
Identifiers
urn:nbn:se:miun:diva-50147 (URN)10.4028/p-xaC6qO (DOI)
Available from: 2023-12-20 Created: 2023-12-20 Last updated: 2023-12-20Bibliographically approved
Khrapov, D., Kozadayeva, M., Koptyug, A., Mishurova, T., Meinel, D., Surmenev, R. & Surmeneva, M. (2023). Geometrical features and mechanical properties of the sheet-based gyroid scaffolds with functionally graded porosity manufactured by electron beam melting. Materials Today Communications, 35, Article ID 106410.
Open this publication in new window or tab >>Geometrical features and mechanical properties of the sheet-based gyroid scaffolds with functionally graded porosity manufactured by electron beam melting
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2023 (English)In: Materials Today Communications, ISSN 2352-4928, Vol. 35, article id 106410Article in journal (Refereed) Published
Abstract [en]

Functionally graded porous scaffolds (FGPS) constructed with pores of different size arranged as spatially continuous structure based on sheet-based gyroid with three different scaling factors of 0.05, 0.1 and 0.2 were produced by electron beam powder bed fusion. The pore dimensions of the obtained scaffolds satisfy the values required for optimal bone tissue ingrowth. Agglomerates of residual powder were found inside all structures, which required post-manufacturing treatment. Using X-ray Computed Tomography powder agglomerations were visualized and average wall thickness, wall-to-wall distances, micro- and macro-porosities were evaluated. The initial cleaning by powder recovery system (PRS) was insufficient for complete powder removal. Additional treatment by dry ultrasonic vibration (USV) was applied and was found successful for gyroids with the scaling factors of 0.05 and 0.1. Mechanical properties of the samples, including quasi-elastic gradients and first maximum compressive strengths of the structures before and after USV were evaluated to prove that additional treatment does not produce structural damage. The estimated quasi-elastic gradients for gyroids with different scaling factors lie in a range between 2.5 and 2.9 GPa, while the first maximum compressive strength vary from 52.5 for to 59.8 MPa, compressive offset stress vary from 46.2 for to 53.2 MPa. 

Place, publisher, year, edition, pages
Elsevier, 2023
Keywords
Additive manufacturing, Electron beam, Functionally graded porous scaffolds, Powder bed fusion, Triply periodic minimal surfaces, X-ray computed tomography
National Category
Materials Engineering
Identifiers
urn:nbn:se:miun:diva-48903 (URN)10.1016/j.mtcomm.2023.106410 (DOI)001042342100001 ()2-s2.0-85162160740 (Scopus ID)
Available from: 2023-07-04 Created: 2023-07-04 Last updated: 2023-08-25Bibliographically approved
Parshin, D. V., Gaifutdinov, R. A., Koptioug, A. & Chupakhin, A. P. (2023). MECHANICS OF SKI SLIDING ON SNOW: CURRENT STATUS AND PROSPECTS. Journal of Applied Mechanics and Technical Physics, 64(4), 693-706
Open this publication in new window or tab >>MECHANICS OF SKI SLIDING ON SNOW: CURRENT STATUS AND PROSPECTS
2023 (English)In: Journal of Applied Mechanics and Technical Physics, ISSN 0021-8944, E-ISSN 1573-8620, Vol. 64, no 4, p. 693-706Article in journal (Refereed) Published
Abstract [en]

Since, in modern high-performance sports, the technical component is decisive, the ski running surface is an important element of cross-country skiing. This paper presents a review of papers on sliding mechanics, discusses modern methods for improving it, and considers the prospects for the development of this area under current energy and environmental conditions. Various factors affecting the sliding mechanics, in particular, snow cover albedo, and microroughness of the ski running surface are analyzed in detail.

Place, publisher, year, edition, pages
Pleiades Publishing Ltd, 2023
National Category
Mechanical Engineering
Identifiers
urn:nbn:se:miun:diva-49792 (URN)10.1134/S0021894423040156 (DOI)001088066000015 ()2-s2.0-85174922910 (Scopus ID)
Available from: 2023-11-08 Created: 2023-11-08 Last updated: 2023-11-16Bibliographically approved
Koptyug, A., Sukhovei, Y., Kostolomova, E., Unger, I. & Kozlov, V. (2023). Novel Strategy in Searching for Natural Compounds with Anti-Aging and Rejuvenating Potential. International Journal of Molecular Sciences, 24(9), Article ID 8020.
Open this publication in new window or tab >>Novel Strategy in Searching for Natural Compounds with Anti-Aging and Rejuvenating Potential
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2023 (English)In: International Journal of Molecular Sciences, ISSN 1661-6596, E-ISSN 1422-0067, Vol. 24, no 9, article id 8020Article in journal (Refereed) Published
Abstract [en]

We suggest a novel approach for searching natural compounds with anti-aging and rejuvenation potential using cell cultures, with a high potential for the further in vivo applications. The present paper discusses ways of defining age for cell populations with large numbers of cells and suggests a method of assessing how young or old a cell population is based on a cell age profile approach. This approach uses experimental distributions of the cells over the cell cycle stages, acquired using flow cytometry. This paper discusses how such a profile should evolve under homeostatic maintenance of cell numbers in the proliferation niches. We describe promising results from experiments on a commercial substance claiming rejuvenating and anti-aging activity acting upon the cultures of human mononuclear cells and dermal fibroblasts. The chosen substance promotes a shift towards larger proportion of cells in synthesis and proliferation stages, and increases cell culture longevity. Further, we describe promising in vivo testing results of a selected food supplement. Based on the described concept of cell age profile and available test results, a strategy to search for natural compounds with regenerative, anti-aging and rejuvenation potential is suggested and proposed for wider and thorough testing. Proposed methodology of age assessment is rather generic and can be used for quantitative assessment of the anti-aging and rejuvenation potential of different interventions. Further research aimed at the tests of the suggested strategy using more substances and different interventions, and the thorough studies of molecular mechanisms related to the action of the substance used for testing the suggested search methodology, are needed. 

Keywords
anti-aging potential, cell age profile, cell culture, cell cycle stages, fibroblasts, flow cytometry, mononuclear cells, proliferation niche, regeneration, rejuvenation, search strategy
National Category
Basic Medicine
Identifiers
urn:nbn:se:miun:diva-48386 (URN)10.3390/ijms24098020 (DOI)000987554200001 ()37175723 (PubMedID)2-s2.0-85159334077 (Scopus ID)
Available from: 2023-05-30 Created: 2023-05-30 Last updated: 2023-06-02Bibliographically approved
Koptyug, A. V., Sukhovei, Y. G. & Victor A, G. (2023). Possible Existence of the Relict Mechanism of Cell Protection During Division. Biomedical Journal of Scientific & Technical Research, 51(3)
Open this publication in new window or tab >>Possible Existence of the Relict Mechanism of Cell Protection During Division
2023 (English)In: Biomedical Journal of Scientific & Technical Research, E-ISSN 2574-1241, Vol. 51, no 3Article in journal (Refereed) Published
Abstract [en]

Antibacterial properties of the stem cells and human- and plant- derived microvesicles are attracting increasing attention of the research community. Awareness of publications pointing out to the pronounced anti-bacterial properties of microvesicles isolated from the supernatants of different human origin prompted us to test corresponding properties of supernatant isolated using simplified protocol. Extensive research with more than 100 laboratory strains and hospital isolates of Gram-positive and Gram- negative bacteria point out to a pronounced anti-bacterial activity of the supernatant isolated from the cultures of actively dividing human cells. Simultaneous support of cell proliferation homeostasis and anti-bacterial activity led us to the hypotheses suggesting that there exists some archaic (possibly relict) mechanism with bivalent activity, which is provided by certain entities present in the supernatant. Taking into account that dried supernatant does not lose its potency for relatively long time, we would like to attract activity of wide research community to the opening application possibilities, and to the critical discussions over the formulated hypothesis.

Keywords
Cell Culture, Proliferation, Apoptosis, Homeostasis, Supernatant, Microvesicles, Exosomes, Antibacterial Properties
National Category
Other Materials Engineering
Identifiers
urn:nbn:se:miun:diva-50128 (URN)10.26717/bjstr.2023.51.008112 (DOI)
Available from: 2023-12-18 Created: 2023-12-18 Last updated: 2023-12-18Bibliographically approved
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ORCID iD: ORCID iD iconorcid.org/0000-0003-2964-9500

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