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Cheema, H. A., Jafar, U., Shahid, A., Masood, W., Usman, M., Hermis, A. H., . . . Lee, K. Y. (2024). Colchicine for the treatment of patients with COVID-19: an updated systematic review and meta-analysis of randomised controlled trials. BMJ Open, 14(4), Article ID e074373.
Open this publication in new window or tab >>Colchicine for the treatment of patients with COVID-19: an updated systematic review and meta-analysis of randomised controlled trials
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2024 (English)In: BMJ Open, E-ISSN 2044-6055, Vol. 14, no 4, article id e074373Article, review/survey (Refereed) Published
Abstract [en]

OBJECTIVES: We conducted an updated systematic review and meta-analysis to investigate the effect of colchicine treatment on clinical outcomes in patients with COVID-19. DESIGN: Systematic review and meta-analysis. DATA SOURCES: We searched PubMed, Embase, the Cochrane Library, medRxiv and ClinicalTrials.gov from inception to January 2023. ELIGIBILITY CRITERIA: All randomised controlled trials (RCTs) that investigated the efficacy of colchicine treatment in patients with COVID-19 as compared with placebo or standard of care were included. There were no language restrictions. Studies that used colchicine prophylactically were excluded. DATA EXTRACTION AND SYNTHESIS: We extracted all information relating to the study characteristics, such as author names, location, study population, details of intervention and comparator groups, and our outcomes of interest. We conducted our meta-analysis by using RevMan V.5.4 with risk ratio (RR) and mean difference as the effect measures. RESULTS: We included 23 RCTs (28 249 participants) in this systematic review. Colchicine did not decrease the risk of mortality (RR 0.99; 95% CI 0.93 to 1.05; I2=0%; 20 RCTs, 25 824 participants), with the results being consistent among both hospitalised and non-hospitalised patients. There were no significant differences between the colchicine and control groups in other relevant clinical outcomes, including the incidence of mechanical ventilation (RR 0.75; 95% CI 0.48 to 1.18; p=0.22; I2=40%; 8 RCTs, 13 262 participants), intensive care unit admission (RR 0.77; 95% CI 0.49 to 1.22; p=0.27; I2=0%; 6 RCTs, 961 participants) and hospital admission (RR 0.74; 95% CI 0.48 to 1.16; p=0.19; I2=70%; 3 RCTs, 8572 participants). CONCLUSIONS: The results of this meta-analysis do not support the use of colchicine as a treatment for reducing the risk of mortality or improving other relevant clinical outcomes in patients with COVID-19. However, RCTs investigating early treatment with colchicine (within 5 days of symptom onset or in patients with early-stage disease) are needed to fully elucidate the potential benefits of colchicine in this patient population. PROSPERO REGISTRATION NUMBER: CRD42022369850. 

Place, publisher, year, edition, pages
BMJ, 2024
Keywords
CLINICAL PHARMACOLOGY, COVID-19, VIROLOGY
National Category
Pharmacology and Toxicology
Identifiers
urn:nbn:se:miun:diva-51257 (URN)10.1136/bmjopen-2023-074373 (DOI)001206525600008 ()38631824 (PubMedID)2-s2.0-85190895071 (Scopus ID)
Available from: 2024-04-30 Created: 2024-04-30 Last updated: 2024-06-24
Odoom, D., Mensah, E. O., Dick-Sagoe, C., Lee, K. Y., Opoku, E. & Obeng-Baah, J. (2024). Examining the level of public awareness on the Sustainable Development Goals in Africa: An empirical evidence from Ghana. Environment, Development and Sustainability, 26(3), 6221-6238
Open this publication in new window or tab >>Examining the level of public awareness on the Sustainable Development Goals in Africa: An empirical evidence from Ghana
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2024 (English)In: Environment, Development and Sustainability, ISSN 1387-585X, E-ISSN 1573-2975, Vol. 26, no 3, p. 6221-6238Article in journal (Refereed) Published
Abstract [en]

Nations which are part of the United Nations are required to institute appropriate measures to fulfil the vision of the Sustainable Development Goals (SDGs). However, for this to be possible, all stakeholders including the general public need to be fully aware of the SDGs. This research examined the level of public awareness about the SDGs among Ghanaians based on the views of 431 respondents. Means, standard deviation, Mann–Whitney U test, Kruskal Wallis and Pearson Product-Moment Correlations were used for data analysis. The study found that awareness level on SDG 1 (ending poverty), SDG 2 (zero hunger, food security, nutrition and sustainable agriculture), SDG 3 (health and well-being), SDG 5 (gender equality), and SDG 6 (clean water and sanitation) was high among Ghanaians. However, awareness level on SDG 9 (industry, innovation and infrastructure), SDG 14 (conservation of life below water), and SDG 16 (peace, justice and strong institutions) was very low among Ghanaians. No significant difference manifested in the level of awareness among male and female Ghanaians. There were statistically significant differences in educational levels of respondents and their overall level of awareness of the SDGs. Also, there was a low, negative correlation between overall level of awareness and the effectiveness of the communication strategies used in creating awareness about the SDGs. Government should re-examine its communication strategies on the SDGs and put in place a more effective communication policy framework which involves grassroots populations and local communities. 

Place, publisher, year, edition, pages
Springer Nature, 2024
Keywords
Communication, Communication strategy, Public awareness, SDGs, Sustainable development
National Category
Agricultural Science, Forestry and Fisheries
Identifiers
urn:nbn:se:miun:diva-47515 (URN)10.1007/s10668-023-02959-x (DOI)000920988900002 ()2-s2.0-85146949339 (Scopus ID)
Available from: 2023-02-07 Created: 2023-02-07 Last updated: 2024-02-28Bibliographically approved
Khuzaiyah, S., Adnani, Q. E., Muthoharoh, A., Chabibah, N., Widyastuti, W., Susiatmi, S. A., . . . Lee, K. (2024). Indonesian COVID-19 lesson: A mixed-methods study on adolescent health status and health services during pandemic. Journal of Child and Adolescent Psychiatric Nursing, 37(2), Article ID e12457.
Open this publication in new window or tab >>Indonesian COVID-19 lesson: A mixed-methods study on adolescent health status and health services during pandemic
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2024 (English)In: Journal of Child and Adolescent Psychiatric Nursing, ISSN 1073-6077, E-ISSN 1744-6171, Vol. 37, no 2, article id e12457Article in journal (Refereed) Published
Abstract [en]

Topic: The COVID-19 pandemic affected adolescents' physical and psychological health. There must be specific services to cater to the needs of adolescents during COVID-19 in Indonesia. Lessons learned from previous pandemics will be beneficial for nurses and other health professionals to prepare services for future pandemics. Purpose: This mixed-method study aimed to examine 459 Indonesian adolescents' health, literacy, preventive measures, and preferred health services during the COVID-19 pandemic. This study also examines sociodemographics, respondent characteristics, health information sources, and media choices. Results: A total of 47.5% of adolescents knew about COVID-19, 26.8% experienced physical health changes, and 61.7% considered wearing masks. Adolescent health information came from teachers (26.6%) and the Internet (32.9%). Psychological changes showed 67.8% irritation. Indonesians preferred online counseling (53.8%) and WhatsApp (45.8%) for pandemic health services. COVID-19 literacy did not affect physical or mental health (p > 0.05). Conclusions: Most adolescents reported mental and physical health changes during COVID-19. Our data suggest that adolescents' strong COVID−19 knowledge did not prevent anxiety and other psychological difficulties. The longitudinal studies could be utilized if pandemic demands social and physical distance. The government, as well as nurses, might utilize WhatsApp-based remote online treatment for health services. 

Place, publisher, year, edition, pages
Wiley, 2024
Keywords
adolescent, adolescent health, COVID-19, humans, Indonesia, literacy, pandemics
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
urn:nbn:se:miun:diva-50868 (URN)10.1111/jcap.12457 (DOI)001179141800001 ()38433114 (PubMedID)2-s2.0-85186614194 (Scopus ID)
Available from: 2024-03-13 Created: 2024-03-13 Last updated: 2024-03-22Bibliographically approved
Cheema, H. A., Abdul Rab, S., Butt, M., Jafar, U., Shahid, A., Rehman, A. U., . . . Sah, R. (2024). Molnupiravir for the treatment of COVID-19 outpatients: An updated meta-analysis. Journal of Microbiology, Immunology and Infection, 57(3), 396-402
Open this publication in new window or tab >>Molnupiravir for the treatment of COVID-19 outpatients: An updated meta-analysis
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2024 (English)In: Journal of Microbiology, Immunology and Infection, ISSN 1684-1182, Vol. 57, no 3, p. 396-402Article in journal (Refereed) Published
Abstract [en]

Background: The majority of available data on molnupiravir come from an unvaccinated COVID-19 population. Therefore, we conducted this meta-analysis to integrate evidence from recent randomized controlled trials (RCTs) as well as observational studies stratified by vaccination status to determine the clinical efficacy and safety of molnupiravir in COVID-19 outpatients. Methods: We searched PubMed, Embase, the Cochrane Library, medRxiv, and ClinicalTrials.gov from inception to November 2023. We conducted our meta-analysis using RevMan 5.4 with risk ratio (RR) as the effect measure. Results: We included 8 RCTs and 5 observational studies in our meta-analysis. Molnupiravir reduced the risk of all-cause mortality (RR 0.28; 95% CI: 0.20–0.79, I2 = 0%) but did not decrease the hospitalization rate (RR 0.67; 95% CI: 0.45–1.00, I2 = 53%) in the overall population; in the immunized population, no benefits were observed. Molnupiravir lowered the rate of no recovery (RR 0.78; 95% CI: 0.76–0.81, I2 = 0%) and increased virological clearance at day 5 (RR 2.68; 95% CI: 1.94–4.22, I2 = 85%). There was no increase in the incidence of adverse events. Conclusions: Molnupiravir does not decrease mortality and hospitalization rates in immunized patients with COVID-19. However, it does shorten the disease course and increases the recovery rate. The use of molnupiravir will need to be considered on a case-by-case basis in the context of the prevailing social circumstances, the resource setting, drug costs, and the healthcare burden. 

Place, publisher, year, edition, pages
Elsevier BV, 2024
Keywords
COVID-19, EIDD-2801, MK-4482, Molnupiravir, SARS-CoV-2
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
urn:nbn:se:miun:diva-51088 (URN)10.1016/j.jmii.2024.03.002 (DOI)001263634800001 ()38555274 (PubMedID)2-s2.0-85189005582 (Scopus ID)
Available from: 2024-04-09 Created: 2024-04-09 Last updated: 2024-08-07
Omar Bali, A., Ahmad, A. R., Omer, E. & Lee, K. Y. (2024). Public engagement with pictures and videos about COVID-19 vaccination on social media: A cross-sectional study in a developing country. International Journal of Healthcare Management
Open this publication in new window or tab >>Public engagement with pictures and videos about COVID-19 vaccination on social media: A cross-sectional study in a developing country
2024 (English)In: International Journal of Healthcare Management, ISSN 2047-9700, E-ISSN 2047-9719Article in journal (Refereed) Epub ahead of print
Abstract [en]

Vaccination is a critical component of preventing infectious diseases and is one of the most effective public health interventions. While social media is an essential source of health and medical information, it is crucial to understand the link between social media involvement and vaccination engagement. This study examines the relationship between COVID-19 vaccination and social media in Iraq. A web-based questionnaire was administered through Google Forms to elicit responses from a total of 2088 Iraqi social media users aged 18 years and over. The findings suggested significant differences in vaccination engagement due to the level of use of social media and demographic backgrounds, particularly age, educational attainment, and income. Active users and young-aged groups with less educational level and income were more likely to have a positive attitude toward vaccination. Future studies should address demographics and the extent of using social media factors in public health studies. Our findings support the use of social media in raising health awareness. 

Place, publisher, year, edition, pages
Informa UK Limited, 2024
Keywords
COVID-19, public engagement, social media, vaccination, vaccine
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
urn:nbn:se:miun:diva-51253 (URN)10.1080/20479700.2024.2331913 (DOI)001205231800001 ()2-s2.0-85191077901 (Scopus ID)
Available from: 2024-04-30 Created: 2024-04-30 Last updated: 2024-05-13
Zubair, R., Zulfi, M. H., Yaqoob, U. & Lee, K. Y. (2024). Subcutaneous fibroblastoma resembling hemangioma: A case of benign tumor of the chest wall. Clinical Case Reports, 12(4), Article ID e7523.
Open this publication in new window or tab >>Subcutaneous fibroblastoma resembling hemangioma: A case of benign tumor of the chest wall
2024 (English)In: Clinical Case Reports, E-ISSN 2050-0904, Vol. 12, no 4, article id e7523Article in journal (Refereed) Published
Abstract [en]

Key Clinical MessageDesmoplastic fibroma presents similar to other soft tissue tumors to such an extent that even a gold standard investigation can miss.AbstractThis is to report a mass in a 47-year-old male arising from the chest wall, which was first thought to be a hemangioma but was later diagnosed as a case of desmoplastic fibroblastoma with the help of a biopsy. 

Place, publisher, year, edition, pages
Wiley, 2024
Keywords
chest wall tumors, desmoplastic fibroblastoma, hemangioma, soft tissue tumors, subcutaneous fibroblastoma
National Category
Cancer and Oncology
Identifiers
urn:nbn:se:miun:diva-51052 (URN)10.1002/ccr3.7523 (DOI)001193930300001 ()38562578 (PubMedID)
Available from: 2024-04-05 Created: 2024-04-05 Last updated: 2024-04-05
Sarder, M. A., Lee, K. Y., Keramat, S. A., Hashmi, R. & Ahammed, B. (2023). A multilevel analysis of individual and community-level factors associated with childhood immunisation in Bangladesh: Evidence from a pooled cross-sectional survey. Vaccine: X, 14, Article ID 100285.
Open this publication in new window or tab >>A multilevel analysis of individual and community-level factors associated with childhood immunisation in Bangladesh: Evidence from a pooled cross-sectional survey
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2023 (English)In: Vaccine: X, E-ISSN 2590-1362, Vol. 14, article id 100285Article in journal (Refereed) Published
Abstract [en]

Introduction: Previous studies on childhood vaccinations in Bangladesh relied on single-level analyses and ignored the clustering and hierarchical structure of data collected from people living in different geographical units. This study, therefore, aimed to investigate the association between individual and community-level factors of full childhood immunisation with an improved analytical approach. Methods: Participants were 13,752 children aged 12–59 months. Data were extracted from the Bangladesh Demographic and Health Survey (BDHS) conducted in 2007, 2011, 2014, and 2017–18. A two-level multilevel logistic regression method was used to analyse the data. Results: Approximately 87% of the children were fully immunised. In the fully adjusted model, at the individual level, mothers who had primary and above education (Adjusted odds ratio [AOR] = 1.78; 95% Confidence Interval [CI]: 1.57, 2.01), mass media exposure (AOR = 1.14; 95% CI: 1.00, 1.30), having vaccination cards (AOR = 3.65; 95% CI: 3.23, 4.14), and having at least 4 antenatal care (ANC) visits (AOR = 1.24; 95% CI: 1.06, 1.44) were strongly associated with full childhood immunisation. At community-level, rural residency (AOR = 1.25; 95% CI: 1.08, 1.44), community women's education (AOR = 1.24; 95% CI: 1.07, 1.43), and community ANC utilisation (AOR = 1.38; 95% CI: 1.19, 1.61) were significantly associated with full childhood immunisation. Conclusion: Along with individual-level factors, community-level factors have a significant effect on childhood immunisation. Policymakers should target improving community-level characteristics, such as community poverty, education levels, and the number of community-level ANC visits, to increase the national level of childhood immunisation. Public health intervention programs aiming at increasing awareness of childhood immunisation should include elements at both individual and community levels. © 2023 The Author(s)

Keywords
Bangladesh, Childhood immunisation, Community-level factors, Individual-level factors, Multilevel modelling
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
urn:nbn:se:miun:diva-48117 (URN)10.1016/j.jvacx.2023.100285 (DOI)000972393800001 ()2-s2.0-85151276009 (Scopus ID)
Available from: 2023-04-12 Created: 2023-04-12 Last updated: 2024-05-21Bibliographically approved
Arshad, W., Maqbool, S., Kiany, J. A., Raza, A., Farooq, U., Ali, Q. & Lee, K. Y. (2023). A rare case of retropharyngeal liposarcoma: a rare location of a rare diagnosis. Journal of Surgical Case Reports, 2023(3), Article ID rjad106.
Open this publication in new window or tab >>A rare case of retropharyngeal liposarcoma: a rare location of a rare diagnosis
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2023 (English)In: Journal of Surgical Case Reports, E-ISSN 2042-8812, Vol. 2023, no 3, article id rjad106Article in journal (Refereed) Published
Abstract [en]

We report a case of retropharyngeal liposarcoma in a 53-year-old female, who had complaints of neck swelling accompanied with dysphagia, orthopnea and dysphonia. Clinical examination revealed huge multinodular swelling in front of neck with bilateral extension, more prominent on left side and moving with deglutition. The diagnosis of retropharyngeal liposarcoma was established following CT scan, MRI and incisional biopsy. Surgical excision of mass along with near total thyroidectomy was performed. Postoperative hospital stay was uneventful. She remained well in follow-up period of 1 year as well. In conclusion, retropharyngeal liposarcoma is a rare tumor. A review of the literature explores the reasons behind the late presentation as well as the difficulties in diagnosis and treatment of this rare tumor.

Keywords
Liposarcoma, retropharyngeal space, retropharyngeal liposarcoma
National Category
Clinical Medicine
Identifiers
urn:nbn:se:miun:diva-48058 (URN)10.1093/jscr/rjad106 (DOI)000946135100013 ()36896154 (PubMedID)
Available from: 2023-04-03 Created: 2023-04-03 Last updated: 2024-01-09Bibliographically approved
Magtalas, M. C., Balbin, P. T., Cruz, E. C., Guevarra, R. C., Cruz, A. R., Silverio, C. E., . . . Tantengco, O. A. (2023). A systematic review of ethnomedicinal plants used for pregnancy, childbirth, and postpartum care in the Philippines. Phytomedicine Plus, 3(1), Article ID 100407.
Open this publication in new window or tab >>A systematic review of ethnomedicinal plants used for pregnancy, childbirth, and postpartum care in the Philippines
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2023 (English)In: Phytomedicine Plus, ISSN 2667-0313, Vol. 3, no 1, article id 100407Article, review/survey (Refereed) Published
Abstract [en]

Background: Medicinal plants are still widely used in rural areas of the Philippines. Among the conditions treated with medicinal plants are those related to pregnancy, childbirth, and postpartum care. This systematic review identified the medicinal plants used for obstetric care in the country. Methods: The study was conducted based on the PRISMA flow diagram, starting with a data search using three databases. The necessary information was extracted from the eligible research papers, and the studies' quality was assessed through a developed quality assessment tool. Results: This study included 38 ethnobotanical studies with 153 plant species used for pregnancy and postpartum care. Most of the studies were conducted in Northern Mindanao, in the Philippines. The most common pregnancy-related indications for the medicinal plants were postpartum care, and postpartum bleeding topped the list. The most common plant family, genus, and species were Fabaceae, Ficus, and Moringa oleifera Lam, respectively. The leaf was the most common single plant part used for pregnancy and postpartum care. Only 80 medicinal plants had toxicologic and teratogenic data. Conclusion: Women from different ethnic groups widely utilized medicinal plants to treat pregnancy-related conditions. Further research on toxicology and teratogenicity is necessary to ensure the safety of their users. 

Keywords
Ethnobotany, Herbal medicine, Medicinal plants, Obstetrics, Traditional medicine
National Category
Obstetrics, Gynecology and Reproductive Medicine
Identifiers
urn:nbn:se:miun:diva-47422 (URN)10.1016/j.phyplu.2023.100407 (DOI)2-s2.0-85146466765 (Scopus ID)
Available from: 2023-01-31 Created: 2023-01-31 Last updated: 2023-01-31Bibliographically approved
Magtalas, M. C., Balbin, P. T., Cruz, E. C., Adizas, A. V., Gerardo, J. P., Sausa, R. B., . . . Tantengco, O. A. (2023). A systematic review of medicinal plants used in the treatment of gynecologic diseases in the Philippines. Phytomedicine Plus, 3(3), Article ID 100462.
Open this publication in new window or tab >>A systematic review of medicinal plants used in the treatment of gynecologic diseases in the Philippines
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2023 (English)In: Phytomedicine Plus, ISSN 2667-0313, Vol. 3, no 3, article id 100462Article, review/survey (Refereed) Published
Abstract [en]

Background: Different indigenous peoples in the Philippines still utilize medicinal plants in treating gynecologic diseases. However, there is a lack of information regarding these medicinal plants used in treating gynecologic conditions in the Philippines. Hence, this systematic review compiled the available literature on medicinal plants used for gynecologic healthcare by various indigenous groups in the Philippines. Methods: Ethnobotanical studies that reported medicinal plants used for gynecologic diseases were obtained from OVID Medline, Scopus, and EBSCO CINAHL. A review of titles, abstracts, and articles was done independently by four reviewers. The quality of the studies was assessed using the quality assessment tool for ethnobotanical studies. Results: A total of 27 studies, including 98 different records, that cited the use of medicinal plants to treat gynecologic diseases were included in the qualitative synthesis. Most ethnobotanical studies were conducted in Northern Mindanao, Central Luzon, and Caraga, Philippines. The most common plant family, genus, and species were Fabaceae, Mimosa, and Mimosa pudica L., respectively. Leaves, roots, and stems were predominantly used, commonly prepared by decoction. Medicinal plants reported in ethnobotanical studies were widely used to treat dysmenorrhea (34 ssp.), irregular menstruation (28 spp.), myoma (four spp.), and infertility (four spp.). A significant proportion of medicinal plants used to treat gynecologic diseases in the Philippines had records of toxicologic (18 spp., 31.03%) or teratogenic (one sp., 1.72%) properties. Other species were reported as both nontoxic and toxic (five spp., 8.62%) and toxic and teratogenic (one sp., 1.72%). However, some were nontoxic or teratogenic (11 sp., 18.97%). In addition, 22 plant species had no data on toxicity or teratogenicity. Conclusion: This systematic review showed that medicinal plants and traditional healing practices are crucial in gynecologic healthcare in the Philippines. 

Place, publisher, year, edition, pages
Elsevier, 2023
Keywords
Ethnobotany, Gynecology, Medicinal plants, Philippines, Review, Traditional medicine
National Category
Obstetrics, Gynecology and Reproductive Medicine
Identifiers
urn:nbn:se:miun:diva-49022 (URN)10.1016/j.phyplu.2023.100462 (DOI)2-s2.0-85163395583 (Scopus ID)
Available from: 2023-08-15 Created: 2023-08-15 Last updated: 2023-08-15Bibliographically approved
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